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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Development of regenerative and flexible fibroin-based wound dressings
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Development of regenerative and flexible fibroin-based wound dressings

机译：促进纤维素的卷绕敷料的发展

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摘要

Skin injuries represent a health problem with consequences in terms of morbidity, disability and life quality. Numerous strategies have been developed for the treatment of wounds, including skin substitutes, biomembranes, scaffolds, and smart dressings. The excellent properties of fibroin can be exploited for the development of advanced wound dressing biomaterials, aiming at promoting the wound healing process. In this work, silk fibroin films modified through the addition of glucose were developed to enhance flexibility of medical device without affecting the biocompatibility, to promote wound healing and to improve the patient well-being. The glucose/fibroin blend was characterized through Fourier transform infrared spectroscopy and differential scanning calorimetry to analyze the protein structure. Absorption capacity, mechanical properties, wettability and bacterial biofilm formation on silk fibroin films were also analyzed to study the effect of the addition of a plasticizer on the properties of the wound dressing. The stability of the films was analyzed through in vitro biodegradability tests. The biocompatibility and regenerative properties were demonstrated through appropriate cellular assays. The results demonstrated that the addition of glucose induced crystallization and provided good flexibility and absorption capacity of silk fibroin films. Glucose modified silk fibroin films were biocompatible and had a positive effect in promoting the wound closure. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 107B: 7-18, 2019.
机译：皮肤伤害代表了发病率，残疾和生活质量的后果的健康问题。为伤口的治疗而开发了许多策略，包括皮肤替代品，生物蛋白质，支架和智能敷料。纤维素的优异性质可以利用先进的伤口敷料生物材料，旨在促进伤口愈合过程。在这项工作中，通过添加葡萄糖改性的丝素蛋白薄膜来增强医疗器械的柔韧性而不影响生物相容性，以促进伤口愈合并改善患者阱。通过傅里叶变换红外光谱和差示扫描量热法表征葡萄糖/纤维素混合物，以分析蛋白质结构。还分析了在丝素蛋白膜上的吸收能力，机械性能，润湿性和细菌生物膜形成，研究增塑剂对伤口敷料性能的影响。通过体外生物降解性试验分析膜的稳定性。通过适当的细胞测定来证明生物相容性和再生性能。结果表明，添加葡萄糖诱导的结晶并提供丝素蛋白膜的良好柔韧性和吸收能力。葡萄糖改性丝素蛋白薄膜是生物相容性的，并且在促进伤口闭合方面具有积极的效果。 （c）2018 Wiley期刊，Inc .J生物保解员B部分B：Appl Biomater，107B：7-18，2019。

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