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Sterilization of Ginseng Using a High Pressure CO2 at Moderate Temperatures

机译：在高温下使用高压CO2对人参进行灭菌

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The aim of this Study was to determine the feasibility of using high pressure CO, for sterilization of Ginseng powder, as an alternative method to conventional techniques such as gamma-irradiation and ethylene oxide. The Ginseng sample used in this study was originally contaminated with fungi and 5 x 10(7) bacteria/g that was not Suitable for oral use. This is the first time that high pressure CO, has been used for the sterilization of herbal medicine to decrease the total aerobic microbial count (TAMC) and fungi. The effect of the process duration, operating Pressure, temperature, and amount Of additives oil the sterilization efficiency Of high Pressure CO2 Were investigated. The process duration was varied over 15 h; the pressure between 100 and 200 bar and the temperature between 25 and 75 degrees C. A 2.67-log reduction of bacteria in the Ginseng sample was achieved after long treatment time of 15 h at 60 degrees C and 100 bar, when using near carbon dioxide. However, the addition of a small quantity of water/ethanol/H2O2 mixture, as low as 0.02 mL of each additive/g Ginseng powder, was sufficient for complete inactivation of fungi within 6 h at 60 degrees C and 100 bar. At these conditions the bacterial count was decreased from 5 x 10(7) to 2.0 x 10(3) TAMC/g complying with the TGA standard for orally ingested products. A 4.3 log reduction in bacteria was achieved at 150 bar and 30 degrees C, decreasing the TAMC in Ginseng sample to 2,000, below the allowable limit. However, fungi still remained in the sample. The complete inactivation of both bacteria and fungi was achieved within 2 h at 30 degrees C and 170 bar using 0.1 mL of each additive/g Ginseng. Microbial inactivation at this low temperature opens an avenue for the sterilization of many thermally labile pharmaceutical and food products that may involve sensitive compounds to gamma-radiation and chemically reactive antiseptic agents.
机译：这项研究的目的是确定使用高压CO对人参粉进行灭菌的可行性，作为对常规技术（如伽马射线辐照和环氧乙烷）的替代方法。本研究中使用的人参样品最初被真菌和5 x 10（7）细菌/ g污染，不适合口服。这是第一次将高压CO用于草药灭菌，以减少总需氧微生物数量（TAMC）和真菌。研究了工艺持续时间，操作压力，温度和添加剂油量的影响，研究了高压CO2的灭菌效率。过程持续时间超过15小时;在100至200巴之间的压力和25至75摄氏度之间的温度。在接近二氧化碳的条件下，在60摄氏度和100巴下经过15小时的长时间处理后，人参样品中的细菌减少了2.67对数。但是，添加少量的水/乙醇/ H2O2混合物（每种添加剂/克人参粉的量低至0.02 mL）足以在60摄氏度和100巴下6小时内使真菌完全灭活。在这些条件下，细菌数量从5 x 10（7）降低至2.0 x 10（3）TAMC / g，符合口服产品的TGA标准。在150巴和30摄氏度下，细菌减少了4.3 log，使人参样品中的TAMC降低到2,000，低于允许的极限。但是，真菌仍保留在样品中。使用0.1 mL每种添加剂/克人参在30摄氏度和170巴下2小时内，细菌和真菌均完全失活。在这种低温下微生物的灭活为许多对热不稳定的药品和食品的灭菌开辟了一条途径，其中可能涉及对伽马辐射敏感的化合物和化学反应性杀菌剂。

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