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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Injectable biphasic calcium phosphate cements as a potential bone substitute
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Injectable biphasic calcium phosphate cements as a potential bone substitute

机译：可注射的双相磷酸钙水泥作为潜在的骨替代品

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Apatitic calcium phosphate cements (CPCs) have been widely used as bone grafts due to their excellent osteoconductive properties, but the degradation properties are insufficient to stimulate bone healing in large bone defects. A novel approach to overcome the lack of degrad-ability of apatitic CPC involves the development of biphasic CPCs (BCPC) based on tricalcium phosphate (TCP) in both alpha- and beta-polymorphs. The aim of the current study was to prepare and analyze the physicochemical properties of BCPCs based on dual phase alpha/beta-TCP as obtained by heat treatment of pure alpha-TCP. The handling and mechanical characteristics of the samples as well as the degradation behavior under in vitro condition were investigated and compared with a standard monophasic alpha-TCP-based CPC. The results showed that different heat treatments of commercially available alpha-TCP allowed the formation of biphasic calcium phosphate powder with a variety of alpha/beta-TCP ratios. The use of biphasic powder particles as a reactant for CPCs resulted into increased setting and injectability times of the final BCPCs. During hardening of the cements, the amount of apatite formation decreased with increasing beta-TCP content in the biphasic precursor powders. The morphology of the monophasic CPC consisted of plate-like crystals, whereas needle-like crystals were observed for BCPCs. In vitro degradation tests demonstrated that dissolution rate and corresponding calcium release from the set cements increased considerably with increasing beta-TCP content, suggesting that apatitic CPCs can be rendered degradable by using biphasic alpha/beta-TCP as powder precursor phase.
机译：由于其优异的骨导电性能，磷酸钙钙水泥（CPC）已被广泛用作骨移植物，但是降解特性不足以刺激大骨缺损中的骨愈合。克服缺乏磷灰石CPC缺乏降低能力的新方法涉及基于α-和β-多晶型物中的磷酸三钙（TCP）的双相CPC（BCPC）的发展。目前研究的目的是基于通过纯α-TCP的热处理获得的双相α/β-TCP制备和分析BCPC的物理化学特性。研究了样品的处理和机械特性以及体外条件下的降解行为，并与标准的单表基础α-TCP的CPC进行比较。结果表明，商业上可获得的α-TCP的不同热处理允许形成具有多种α/β-TCP比率的双相磷酸钙粉末。使用双相粉末颗粒作为CPC的反应物导致最终BCPC的设置和可注射时间增加。在水泥的硬化过程中，磷灰石形成的量随着双相前体粉末中的β-TCP含量的增加而降低。单选式CPC的形态由板状晶体组成，而对BCPCs观察到针状晶体。体外降解试验证明，随着β-TCP含量的增加，溶出速率和相应的钙释放随着β-TCP含量的增加而显着增加，表明可以通过使用双相α/β-TCP作为粉末前体阶段来降解磷灰石CPC。

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