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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Properties and in vitro evaluation of high modulus biodegradable polyurethanes for applications in cardiovascular stents
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Properties and in vitro evaluation of high modulus biodegradable polyurethanes for applications in cardiovascular stents

机译：高模量可生物降解聚氨酯对心血管支架应用的性质和体外评价

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This study examined the suitability of a family of biodegradable polyurethanes (PUs) NovoSorb (TM) developed for the vascular stent application. These segmented PUs are formulated to be biodegradable using degradable polyester and PU blocks. A series of PUs comprising different hard segment weight percentage ranging from 60 to 100 were investigated. The mechanical properties of the PUs were evaluated before and after gamma sterilization to assess their suitability for vascular implants. The real-time (PBS/37 degrees C/pH 7.4) hydrolytic degradation studies were carried out under sterile conditions and PU glass transition temperature, molecular weight, and mass loss at 3, 6, and 9 months were determined. The viability and growth of Human Umbilical Vein Endothelial Cells (HUVEC) on PU surfaces were determined to assess the effect of PU degradation. The effect of coating of extracellular matrix (ECM) components on cell viability was also investigated. The study showed that the PUs possess excellent mechanical properties exhibiting high tensile strength (41-56 MPa) and tensile modulus (897-1496 MPa). The PU films maintained mechanical strength during the early phase of the degradation but lost strength at latter stages. The unmodified polymer surface of each PU promotes endothelial cell growth and proliferation, with a HUVEC retention rate of >70%. (C) 2014 Wiley Periodicals, Inc.
机译：本研究检测了为血管支架应用开发的可生物降解的聚氨酯（PUS）Novosorb（PUS）Novosorb（TM）的适用性。配制这些分段的脓液用可降解聚酯和PU块可生物降解。调查了一系列包含60至100的不同硬段重量百分比的脓液。在γ灭菌之前和之后评估PU的力学性能，以评估它们对血管植入物的适用性。在无菌条件下进行实时（PBS / 37摄氏度C / pH 7.4）水解降解研究，测定PU玻璃化转变温度，分子量和3,6和9个月的质量损失。确定PU表面上的人脐静脉内皮细胞（HUVEC）的活力和生长，以评估PU降解的影响。还研究了细胞外基质（ECM）组分对细胞活力的影响。该研究表明，PU具有出色的抗拉强度（41-56MPa）和拉伸模量（897-1496MPa）的优异的机械性能。 PU膜在降解的早期期间保持机械强度，但在后一阶段的损失损失。每个PU的未改性的聚合物表面促进内皮细胞生长和增殖，HUVEC保留率> 70％。 （c）2014 Wiley期刊，Inc。

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