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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Biocompatibility and biomechanical analysis of elastic TPU threads as new suture material
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Biocompatibility and biomechanical analysis of elastic TPU threads as new suture material

机译：弹性TPU螺纹作为新缝合材料的生物相容性及生物力学分析

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High suture tension is one of the causes for many wound-healing problems. Constriction of tissue within the suture loops of nonelastic sutures can lead to cutting of the suture through tissues and necrosis of the tissue within these loops. The use of elastic materials in new suture types could give the material the ability to adapt tension to the tissue requirements and subsequently lead to more vital tissue within its loops. We evaluated the foreign body host response, as indicator of biocompatibility, to a new thermoplastic poly(carbonate) urethane (TPU) synthetic suture material in a rat model compared with standard nonelastic polypropylene (PP) sutures. Tissue samples were collected at 7 and 21 days, and host response was evaluated. Subsequently, suture tension curves of the new elastic sutures for the first 30 min after knotting were recorded in a pig model. The new TPU sutures showed an improved foreign body response when compared with that of PP, with a reduction in the amount of macrophages surrounding the material. Tension experiments showed a superior tension curve for TPU sutures, with a major reduction in peak suture tension when compared with that of standard PP sutures, while still retaining adequate tension after 30 min. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 99-106, 2017.
机译：高缝合张力是许多伤口愈合问题的原因之一。梭形缝合线缝合线环内的组织的收缩可以通过这些环内组织的组织和坏死切割缝合线。在新缝合物类型中使用弹性材料可以使材料能够适应组织要求的张力，随后导致其环内的更重要组织。与标准的壬骨聚丙烯（PP）缝合线相比，我们评估了对大鼠模型中的新型热塑性聚（碳酸盐）聚氨酯（TPU）合成缝合材料的异物宿主响应，作为生物相容性的指标。在7和21天收集组织样品，评价宿主响应。随后，在猪模型中记录了在结后的前30分钟的新弹性缝合线的缝合张力曲线。与PP相比，新的TPU缝合线显示出改善的异物响应，减少了材料周围的巨噬细胞量。张力实验显示TPU缝合线的优异张力曲线，与标准PP缝合线相比，峰值缝合张力的主要减少，同时仍在30分钟后保持足够的张力。 （c）2015年Wiley期刊，Inc。J生物保解率B部分：Appl Biomater，105B：99-106,2017。

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