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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Cyanoacrylate medical glue application in intervertebral disc annulus defect repair: Mechanical and biocompatible evaluation
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Cyanoacrylate medical glue application in intervertebral disc annulus defect repair: Mechanical and biocompatible evaluation

机译：氰基丙烯酸酯医用胶水应用在椎间盘环形缺陷修复：机械和生物相容性评价

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In an attempt to find an ideal closure method during annulus defect repair, we evaluate the use of medical glue by mechanical and biocompatible test. Cyanoacrylate medical glue was applied together with a multilayer microfiber/nanofiber polycaprolactone scaffold and suture in annulus repair. Continuous axial loading and fatigue mechanical test was performed. Furthermore, the in vitro response of mesenchymal stem cell (MSC) to the glue was evaluated by cell viability assay. The in vivo response of annulus tissue to the glue and scaffold was also studied in porcine lumbar spine; histological sections were evaluated after 3 months. Cyanoacrylate glue significantly improved the closure effect in the experimental group with failure load 2825.7 +/- 941.6 N, compared to 774.1 +/- 281.3 N in the control group without glue application (p<0.01). The experimental group also withstood the fatigue test. No toxic effect was observed by in vitro cell culture and in vivo implantation. On the basis of this initial evaluation, the use of cyanoacrylate medical glue improves closure effect with no toxicity in annulus defect repair. This method of annulus repair merits further effectiveness study in vivo. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 14-20, 2017.
机译：为了试图在环形缺陷修复过程中找到理想的闭合方法，我们通过机械和生物相容性测试评估使用医用胶水。氰基丙烯酸酯医用胶用多层微纤维/纳米纤维聚己内酯支架和缝合线施加在一起载体。进行连续轴向载荷和疲劳机械测试。此外，通过细胞活力测定评估间充质干细胞（MSC）对胶水的体外响应。在猪腰椎中还研究了环状组织与胶水和支架的体内响应; 3个月后评估组织学部分。氰基丙烯酸胶胶在对照组中的失效负载2825.7 +/- 941.6 n中显着改善了实验组中的闭合效果，但在没有胶水的情况下，对照组的774.1 +/- 281.3 n相比（P <0.01）。实验组也经受疲劳试验。通过体外细胞培养和体内植入没有观察到毒性效应。在该初步评价的基础上，使用氰基丙烯酸酯医用胶水可提高闭合效果，无毒性在环空缺陷修复中。这种环形修复方法的方法在体内进一步有效性研究。 （c）2015 Wiley期刊，Inc.J生物保解员B部分B：苹果生物摩特，105B：14-20,2017。

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