...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Enhancing surface properties of breast implants by using electrospun silk fibroin
【24h】

Enhancing surface properties of breast implants by using electrospun silk fibroin

机译：使用Electrom il丝素素增强乳房植入物的表面性质

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract In the present study, a new electrospun silk fibroin coating of silicone breast implants with improved biocompatibility and mechanical properties was obtained. Fibrous scaffolds were produced by electrospinning a solution containing silk fibroin, derived from Bombyx mori cocoons, and polyethylene oxide (PEO) to be used as a coating of breast implants. A randomly oriented structure of fibroin/PEO was electrospun on implants as assessed by SEM analysis, roughness measurements and ATR‐FTIR spectroscopy. The scaffold showed 0.25 μm diameter fibres, 0.76 μm size superficial pores, arithmetic roughness of 0.632?±?0.12 μm and texture aspect ratio of 0.893?±?0.04. ATR‐FTIR spectroscopy demonstrates the presence of PEO and fibroin in the coating. The mechanical characterisation of the implants before and after being coated with fibroin/PEO demonstrated that the fibroin/PEO scaffold contributes to the increase in the elastic modulus from 0.392?±?0.02 to 0.560?±?0.03 MPa and to a more elastic behaviour of the breast implants. Using the fibroin/PEO coating, human fibroblasts seeded on this matrix increased viability up to 30% compared to conventional breast implants. Electrospun silk fibroin could represent a clinically compatible, viable form to coat breast implants. Low cytotoxicity by the fibroin coating and its physico‐chemical and mechanical properties may find application in improving breast implants biocompatibility. ? 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1655–1661, 2018.
机译：摘要在本研究中，获得了具有改善的生物相容性和机械性能的硅氧烷乳房植入物的新型电纺丝丝素涂层。通过静电塑性含有丝素蛋白的溶液来制备纤维支架，衍生自Bombyx Mori Cocoons的溶液，以及用作乳房植入物的涂层的聚环氧乙烷（PEO）。通过SEM分析，粗糙度测量和ATR-FTIR光谱评估，在植入物上随机取向的纤维素/ PEO结构。支架显示出0.25μm直径纤维，0.76μm尺寸浅表孔，算术粗糙度为0.632≤0.12μm，纹理纵横比为0.893？±0.04。 ATR-FTIR光谱表明涂层中的PEO和纤维素的存在。在涂有纤维素/ PEO之前和之后的植入物的机械表征证明了纤维素/ PEO支架有助于从0.392〜±0.02至0.560？±0.03 MPa的弹性模量的增加和更有弹性的行为乳房植入物。与常规的乳房植入物相比，使用纤维素/ PEO涂层，在该基质上播种的人成纤维细胞增加了高达30％的活力。 Electromun丝素蛋白可以代表临床相容，可行的形式，以涂覆乳房植入物。通过纤维素涂层的低细胞毒性及其物理化学品和机械性能可以在改善乳房植入物生物相容性方面进行施用。还2017 Wiley期刊，Inc。J生物保解率B：Appl BioMater，106B：1655-1661,2018。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号