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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Zeolite‐loaded alginate‐chitosan hydrogel beads as a topical hemostat
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Zeolite‐loaded alginate‐chitosan hydrogel beads as a topical hemostat

机译：沸石加载的藻酸盐 - 壳聚糖水凝胶珠作为局部止血

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Abstract Hemorrhage is the leading cause of preventable death after a traumatic injury, and the largest contributor to loss of productive years of life. Hemostatic agents accelerate hemostasis and help control hemorrhage by concentrating coagulation factors, acting as procoagulants and/or interacting with erythrocytes and platelets. Hydrogel composites offer a platform for targeting both mechanical and biological hemostatic mechanisms. The goal of this work was to develop hydrogel particles composed of chitosan, alginate, and zeolite, and to assess their potential to promote blood coagulation via multiple mechanisms: erythrocyte adhesion, factor concentration, and the ability to serve as a mechanical barrier to blood loss. Several particle compositions were synthesized and characterized. Hydrogel bead composition was optimized to achieve the highest swelling capacity, greatest erythrocyte adhesion, and minimal in vitro cytotoxicity. These results suggest a polymer hydrogel‐aluminosilicate composite material may serve as a platform for an effective hemostatic agent that incorporates multiple mechanisms of action. ? 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1662–1671, 2018.
机译：摘要出血是创伤后预防死亡的主要原因，以及最大的贡献者损失生命损失。止血剂加速止血，通过浓缩凝血因子来帮助控制出血,起用作促凝血剂和/或与红细胞和血小板相互作用。水凝胶复合材料提供了一种靶向机械和生物止血机制的平台。这项工作的目标是开发由壳聚糖，海藻酸盐和沸石组成的水凝胶颗粒，并评估它们通过多种机制促进血液凝固的潜力：红细胞粘附，因子浓度，以及用作血液损失的机械屏障的能力。合成并表征了几种颗粒组合物。优化水凝胶珠组合物，以达到最高的溶胀容量，最大的红细胞粘附，并且在体外细胞毒性最小。这些结果表明聚合物水凝胶 - 硅铝酸盐复合材料可用作有效止血剂的平台，其包含多种作用机制。还2017 Wiley期刊，Inc。J生物保解员B：Appl Biomater，106B：1662-1671,2018。

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