...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Fabrication of biodegradable foams for deep tissue negative pressure treatments
【24h】

Fabrication of biodegradable foams for deep tissue negative pressure treatments

机译：用于深层组织负压处理的可生物降解泡沫的制备

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

ABSTRACT Devices for negative pressure wound therapy (NPWT) rely on compressible foams operating at the tissue‐device interface. Clinically used foams are nonabsorbable and if used on deep wounds or left in place for an extended period of time, excessive cell ingrowth and formation of granulation tissue into the foam may require a surgical procedure to remove the foam. Foams with fast degradation and with low immunogenicity and fibrotic response are required. Foams composed of combinations of poly(lactide‐ co ‐glycolide) (PLGA), poly(lactide‐ co ‐caprolactone) (PLCL), and polycaprolactone (PCL) were created by combined salt leaching and solvent displacement protocols. In vitro and in vivo degradation studies and mechanical properties of foams were evaluated and compared to clinically used poly(vinyl alcohol) (PVA) foam and PCL foams. Foams composed of PLGA (50:50 lactide:glycolide) of low molecular weight blended with PCL maintained mechanical properties and degraded significantly after 21 days of subcutaneous implantation in rats. The most ideal formulations for use in NPWT were identified as copolymeric PLGA ( M n 3000 Da) at a lactide:glycolide ratio of 50:50 combined with PCL at either a 75:25 or 50:50 ratio, and copolymeric PLGA ( M n 7500 Da) at a lactide:glycolide ratio of 50:50 combined with PCL at a 50:50 ratio. ? 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1998–2007, 2018.
机译：用于负压伤口疗法的抽象装置（NPWT）依赖于在组织装置界面操作的可压缩泡沫。临床使用的泡沫是非可吸收的，如果在深伤或延长的时间内使用，则在延长的时间内，过量的细胞|将造粒组织形成到泡沫中可能需要外科手术以除去泡沫。需要快速降解和低免疫原性和纤维化反应的泡沫。通过组合的盐浸出和溶剂位移方案产生由聚（丙交酯）（PLGA），聚（Lactide-Co-CaproLactone）（PLCL）和聚己内酯（PCL）组成的泡沫。在体外和体内降解研究和泡沫的力学性能，并与临床使用的聚（乙烯醇）（PVA）泡沫和PCL泡沫进行比较。用PCL与PCL保持低分子量的PLGA（50:50丙交酯：乙酰胺）组成的泡沫，在大鼠皮下植入21天后，在21天后显着降解。在丙交酯时鉴定在NPWT中的最理想制剂作为共聚PLGA（M n 3000Da）：乙酰乙酰乙酰比为50:50与PCL以75:25或50:50的比率，和共聚PLGA（M n 7500DA）在丙交酯：乙醇酰胺比例为50:50，50:50的比例结合PCL。还2017年Wiley期刊，Inc。J生物保解员B部分B：苹果生物摩特，106B：1998-2007,2018。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号