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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Evaluation of polyacrylonitrile electrospun nano‐fibrous mats as leukocyte removal filter media
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Evaluation of polyacrylonitrile electrospun nano‐fibrous mats as leukocyte removal filter media

机译：用白细胞去除过滤介质评价聚丙烯腈电纺纳米纤维垫

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Abstract Removal of leukocytes from blood products is the most effective means for elimination of undesirable side effects and prevention of possible reactions in recipients. Micro‐fibrous mats are currently used for removal of leukocytes from blood. In this study, samples of electrospun nano‐fibrous mats were produced. The performance of the produced electrospun nano‐fibrous mats as means of leukocytes removal from fresh whole blood was both evaluated and compared with that of commercially available micro‐fibrous mats. In order to produce the samples, polyacrylonitrile (PAN) nano‐fibrous mats were made under different electrospinning conditions. Mean fiber diameter, pore characterization and surface roughness of the PAN nano‐fibrous mats were determined using image processing technique. In order to evaluate the surface tension of the fabricated mats, water contact angle was measured. The leukocyte removal performance, erythrocytes recovery percent and hemolysis rate of the nano‐fibrous mats were compared. The effectiveness of nano‐fibrous mats in removing leukocyte was established using both scanning electron microscope and optical microscope. Results showed that for given weight, the fabricated nano‐fibrous mats were not only more efficient but also more cost‐effective than their commercial counterparts. Results confirmed that changes in mean fiber diameter, the number of layer and weight of each layer in the absence of any chemical reaction or physical surface modification, the fabricated nano‐fibrous mats were able to remove 5‐log of leukocytes. ? 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1759–1769, 2018.
机译：摘要从血液制品中除去白细胞是消除不良副作用和预防受体中可能反应的最有效手段。目前微纤维垫目前用于从血液中去除白细胞。在这项研究中，制备了Electrom淘纳米纤维垫的样品。产生的电纺纳米纤维垫的性能作为从新鲜全血中除去的白细胞的手段，并与市售的微纤维垫相比。为了生产样品，在不同的静电纺丝条件下制备聚丙烯腈（盘）纳米纤维垫。使用图像处理技术确定平均纤维直径，孔纳米纤维垫的孔表征和表面粗糙度。为了评估制造垫的表面张力，测量水接触角。比较了白细胞去除性能，纳米纤维垫的红细胞恢复百分比和溶血率。使用扫描电子显微镜和光学显微镜建立纳米纤维垫在去除白细胞中的有效性。结果表明，对于给定的重量，制造的纳米纤维垫不仅比他们的商业对应物更有效，而且更具成本效益。结果证实，在没有任何化学反应或物理表面改性的情况下，每层的平均纤维直径，层数和重量的变化，制造的纳米纤维垫能够去除5-次白细胞。还2017年Wiley期刊，Inc。J生物保解员B部分B：苹果生物摩特，106B：1759-1769，2018。

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