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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Extracorporeal magnetic approach to reduce the unwanted side‐effects and improve antibacterial activity of Ag/Fe 3 3 O 4 4 nanocomposites in rat
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Extracorporeal magnetic approach to reduce the unwanted side‐effects and improve antibacterial activity of Ag/Fe 3 3 O 4 4 nanocomposites in rat

机译：体外磁法减少不需要的副作用，改善大鼠Ag / Fe 3 3 O 4 4纳米复合材料的抗菌活性

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Abstract While Ag nanoparticles hold great promise for broad spectrum antibacterial activity, the potential risks of Ag nanoparticles (NPs) on human health remain a challenge. In this study, Ag/Fe 3 O 4 composites have been successfully prepared and characterized by transmission electron microscopy, X‐ray powder diffraction, and Fourier‐transform infrared spectroscopy, and their magnetic and antibacterial properties have been assessed. In vivo results show that the antibacterial effect of 500 μg/mL Ag/Fe 3 O 4 nanocomposites was significantly higher than that of 1000 μg/mL AgNPs after 72 h of treatment ( p ??0.01). Hematoxylin and eosin (HE) staining showed that squamous epithelium and dermis collagen fibers formed in the Ag/Fe 3 O 4 group after 8 days treatment. Wound closure was significantly better for the Ag/Fe 3 O 4 group than for the AgNPs group. On the other hand, there was less Ag in blood, liver, and kidney in the Ag/Fe 3 O 4 group, as more Ag was retained in the wound. According to lactate dehydrogenase, γ‐glutamyl transpeptidase, and reactive oxygen species results, Ag/Fe 3 O 4 nanocomposites caused less unwanted side‐effects. This work presents a new paradigm to reduce the unwanted side‐effects of AgNPs and improve their antibacterial activity, providing a new avenue for wound healing. ? 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2029–2036, 2018.
机译：摘要虽然AG纳米粒子对广谱抗菌活性具有很大的承诺，但AG纳米颗粒（NPS）对人体健康的潜在风险仍然是一项挑战。在该研究中，已经成功制备了Ag / Fe 3 O 4复合材料，并通过透射电子显微镜，X射线粉末衍射和傅立叶变换红外光谱进行了表征，并且已经评估了它们的磁性和抗菌性能。在体内结果表明，500μg/ ml Ag / Fe 3 O 4纳米复合材料的抗菌作用明显高于72小时后的1000μg/ ml AgNP的抗菌作用（p≤≤0.01）。苏木精和曙红（He）染色显示，在8天处理后，在Ag / Fe 3 O 4组中形成鳞状上皮和真皮胶原纤维。对于AG / Fe 3 O 4组而不是agnps组，伤口闭合显着更好。另一方面，血液，肝脏和肾脏在ag / Fe 3 O 4组中较少，随着伤口保留更多Ag。根据乳酸脱氢酶，γ-谷氨酸缩肽酶和反应性氧物质结果，Ag / Fe 3 O 4纳米复合材料造成的不需要的副作用不太受效应。这项工作提出了一种新的范例，以减少agnps的不需要的副作用，改善其抗菌活性，为伤口愈合提供了新的途径。还2017年Wiley期刊，Inc。J生物保解率B部分：苹果生物检索物，106B：2029-2036，2018。

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