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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Efficient cutaneous wound healing using bixin‐loaded PCL nanofibers in diabetic mice
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Efficient cutaneous wound healing using bixin‐loaded PCL nanofibers in diabetic mice

机译：高效的皮肤伤口愈合在糖尿病小鼠中使用苄啡板加载的PCL纳米纤维

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Abstract The present work demonstrated an efficient cutaneous wound healing using Bixin‐loaded polycaprolactone (PCL) nanofibers as a controlled delivery system. The influence of Bixin (Bix) content on PCL nanofiber, Bix‐PCL1(2.5% w/w bix) and Bix‐PCL2 (12.5% w/w bix) formation was investigated using electrical conductivity, attenuated total reflectance infrared spectroscopy, X‐ray diffraction, thermal analysis, and scanning electronic microscopy. The results showed that a greater bixin concentration resulted in higher polymeric solution electrical conductivity. Moreover, higher polymeric solution electrical conductivity provides lower nanofibers in terms of average diameter than pure PCL nanofibers. In vitro release was largely governed by a diffusion‐controlled mechanism. The initial Bixin release domain showed a burst release over the first 10 hours where approximately 30% and 40% of Bixin was released from Bix‐PCL1 and Bix‐PCL2 nanofibers, respectively. The second kinetic domain was comprised of a continuous and slow Bixin release that led to almost 100% of the Bixin being released within 14 days. The results on excisional wound model in induced diabetic mice indicated that the low concentration of Bixin released from loaded Bix‐PCL nanofibers maintain the biological activity of Bixin and is efficient in accelerating the wound healing as well as in reducing the scar tissue area compared with pure PCL nanofibers. Therefore, soft material Bixin‐loaded PCL nanofibers are a promising candidate for use in wound dressing. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1938–1949, 2017.
机译：摘要本作本作有效的皮肤伤口愈合，使用本鑫加载的聚己内酯（PCL）纳米纤维作为受控输送系统。使用电导率研究苄汀（BIX）含量对PCL纳米纤维，BIX-PCL1（2.5％w / w bix）和Bix-pcl 2（12.5％w / w bix）形成的影响，减弱总反射率红外光谱，x-射线衍射，热分析和扫描电子显微镜。结果表明，更大的苄汀浓度导致高分子溶液导电率更高。此外，较高的聚合物溶液导电性在比纯PCL纳米纤维的平均直径方面提供低纳米纤维。体外释放在很大程度上被扩散控制机制控制。最初的苄司释放结构域显示出前10小时的突发释放，其中大约30％和40％的苄簇分别从BIX-PCL1和BIX-PCL2纳米纤维释放。第二动力学结构域由连续且慢的苯胺释放组成，其在14天内导致近100％的苄司释放。诱发糖尿病小鼠的促进伤口模型的结果表明，从负载的Bix-PCL纳米纤维中释放的低浓度释放出苄局的生物活性，并有效地加速伤口愈合以及减少瘢痕组织面积与纯净相比PCL纳米纤维。因此，柔软材料掺入的PCL纳米纤维是用于伤口敷料的有希望的候选者。还2016 Wiley期刊，Inc .J生物保解员AP：Appl Biomater，105B：1938-1949,2017。

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