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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >SEMA3A suspended in matrigel improves titanium implant fixation in ovariectomized rats
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SEMA3A suspended in matrigel improves titanium implant fixation in ovariectomized rats

机译：悬浮在Matrigel中的Sema3a改善了卵巢切除大鼠的钛植入物固定

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Abstract The aim of this study was to evaluate the effect of SEMA3A released from matrigel on implant fixation in ovariectomized (OVX) rats. Sixty female rats were subjected to bilateral ovariectomy. Twelve weeks later, rats were randomly divided into three groups according to implants they accepted: (1) Control, implants with distilled water; (2) Matrigel, implants with matrigel coating; (3) Matrigel?+?SEMA3A, implants with coating of SEMA3A suspended in matrigel. Implants were inserted in metaphysis of proximal tibiae in all animas bilaterally. In vitro release of SEMA3A was tested using enzyme linked immunosorbent assay. In vitro release of SEMA3A was detectable during the first 10 days, and a burst release of was observed during the first 3 days. No significant difference was observed between Control and Matrigel group. The protective effects of SEMA3A in matrigel on peri‐implant bone, implant osseointegration and fixation was confirmed. Compared to matrigel alone, SEMA3A suspended in matrigel increased percent bone volume by 88.7% and 83.3% ( p ??0.01), bone‐to‐implant contact ratio by 148.9% ( p ??0.01), and 24.8% ( p ??0.05), the maximal push‐out force by 149.3% and 209.2% ( p ??0.01) at 4 and 8 weeks after implant insertion, respectively. Surface modification with SEMA3A suspended in matrigel improved implant osseointegration and fixation in the proximal tibiae of OVX rats. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2060–2065, 2017.
机译：摘要本研究的目的是评估Sema3a从Matrigel释放到卵巢切除（OVX）大鼠植入物固定的影响。六十只雌性大鼠进行双侧卵巢切除术。 12周后，根据他们接受的植入物随机将大鼠分为三组：（1）对照，植入蒸馏水; （2）Matrigel，植入Matrigel涂层; （3）Matrigel？+αSema3a，植入涂层Sema3a悬浮在Matrigel中。将植入物插入所有Animas的近端胫骨中的结剂。使用酶联免疫吸附测定测试SEMA3a的体外释放。在前10天期间检测到Sema3a的体外释放，并且在前3天期间观察到突发释放。对照和Matrigel组之间没有观察到显着差异。 Sema3a在Matrigel对Peri植入骨，植入骨整合和固定的保护作用。与单独的Matrigel相比，Sema3a悬浮在Matrigel中，骨体积百分比增加88.7％和83.3％（P 1 0. 0.01），骨对植入接触比148.9％（p≤≤0.01），24.8％ （P？0.05），分别在植入物插入后4和8周的最大推出力分别在4和8周内得到149.3％和209.2％（p≤0.01）。用SEMA3A悬浮在Matrigel中的表面改性改善了OVX大鼠近端胫骨的植入骨整合和固定。还2016 Wiley期刊，Inc。J生物保解率B：苹果生物摩特，105B：2060-2065,2017。

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