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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Sucrose esters improve the colloidal stability of nanoethosomal suspensions of (?)‐epigallocatechin gallate for enhancing the effectiveness against UVB‐induced skin damage
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Sucrose esters improve the colloidal stability of nanoethosomal suspensions of (?)‐epigallocatechin gallate for enhancing the effectiveness against UVB‐induced skin damage

机译：蔗糖酯改善了（α） - EpigallocateChin的纳米甲骨体悬浮液的胶体稳定性，用于增强UVB诱导的皮肤损伤的有效性

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Abstract Nanoethosomal suspensions, composed of phospholipids, ethanol, and water, are novel lipid carriers. These suspensions have been reported to enhance the permeation of drugs into the skin as a result of the interdigitation effect of ethanol on the lipid bilayer of liposomes and by increasing the fluidity of lipids in the stratum corneum . The physical stability of the nanoethosomal suspension is still a critical research problem until now. This study investigated the commercial palm sucrose esters to improve the colloidal stability of nanoethosomal suspensions. The results indicated that palm sucrose esters (PSE) were effective for stabilizing nanoethosomal suspension of (?)‐epigallocatechin gallate (EGCG) from green tea. A PSE concentration of 0.15% was optimal for a nanoethosomal suspension which gave mean diameter 75.5?±?3.5 nm, zeta potential ?30.8?±?3.2 mV and polydispersity index 0.207?±?0.017. Moreover, the effectiveness of stabilization was influenced by the degree of esterification of the sucrose esters: the sucrose polyesters could prolong the stability of nanoethosomes loaded with EGCG to a year, but the sucrose monoesters only provided less than 6 months of stabilization. EGCG nanoethosomal suspension stabilized by sucrose polyesters shows better inhibition effectiveness against UVB‐induced skin damage than native EGCG. The nanoethosomal suspension has the potential for its utilization as skin care and other products. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2416–2425, 2017.
机译：摘要纳米甲骨体悬浮液，由磷脂，乙醇和水组成，是新型脂质载体。据报道，这些悬浮液是通过乙醇对脂质体脂质化双层的血液双层的分叉作用以及增加脂质在地层肌肉中的流动性，增强药物进入皮肤的渗透。纳米甲骨体悬浮液的物理稳定性至今仍然是一个关键的研究问题。本研究研究了商业棕榈蔗糖酯，以改善纳米体悬浮液的胶体稳定性。结果表明，棕榈蔗糖酯（PSE）可有效稳定（α） - EpigallocateChinBallate（EGCG）的纳米甲​​骨体悬浮液。对于纳米甲骨体悬浮液，PSE浓度为0.15％，该纳米体悬浮液得到平均直径75.5？±3.5nm，Zeta电位？30.8？±3.2 mV和多分散指数0.207？±0.017。此外，稳定化的有效性受蔗糖酯的酯化程度的影响：蔗糖聚酯可以延长纳米甲基体的稳定性，该纳米甲基体均为EGCG至一年，但蔗糖单酯仅提供少于6个月的稳定化。通过蔗糖聚酯稳定的EGCG纳米甲骨体悬浮液显示出对UVB引起的皮肤损伤的更好的抑制效果，而不是天然EGCG。纳米体悬浮液具有其作为皮肤护理和其他产品的利用潜力。还2016 Wiley期刊，Inc.J生物保解员B：Appl Biomater，105B：2416-2425,2017。

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