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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Biokinetics and tissue response to ultrananocrystalline diamond nanoparticles employed as coating for biomedical devices
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Biokinetics and tissue response to ultrananocrystalline diamond nanoparticles employed as coating for biomedical devices

机译：用于覆盖生物医学装置涂层的超晶体金刚石纳米粒子的生物动力学和组织反应

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Abstract Although Ultrananocrystalline diamond (UNCD) has been proposed as a coating material for titanium biomedical implants, the biological effects and toxicity of UNCD particles that could eventually detach have not been studied to date. The biokinetics and biological effects of UNCD compared to titanium dioxide (TiO 2 ) nanoparticles was evaluated in vivo using Wistar rats ( n ?=?30) i.p. injected with TiO 2 , UNCD or saline solution. After 6 months, blood, lung, liver, and kidney samples were histologically analyzed. Oxidative damage by membrane lipidperoxidation (thiobarbituric acid reactive substances‐TBARS), generation of reactive oxygen species (superoxide anion‐ O 2 ? ), and antioxidant enzymes (superoxide dismutase‐SOD, catalase‐CAT) was evaluated in lung and liver. Histologic observation showed agglomerates of TiO 2 or UNCD in the parenchyma of the studied organs, though there were fewer UNCD than TiO 2 deposits. In addition, TiO 2 caused areas compatibles with foci of necrosis in the liver and renal hyaline cylinders. Regarding UNCD, no membrane damage (TBARS) or mobilization of enzymatic antioxidants was observed either in lung or liver samples. No variations in O 2 ? generation were observed in lung (Co: 35.1?±?4.02 vs. UNCD: 48?±?9.1, p ??0.05). Conversely, TiO 2 exposure caused production of O 2 ? in alveolar macrophages and consumption of catalase ( p 0.05). The studied parameters suggest that UNCD caused neither biochemical nor histological alterations, and therefore may prove useful as a surface coating for biomedical implants. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2408–2415, 2017.
机译：摘要虽然已经提出了超晶金刚石（UNCOD）作为钛生物医学植入物的涂料，但是迄今为止最终可能最终分离的UNC的颗粒的生物学效应和毒性。使用Wistar大鼠（n？= 30）I.p，在体内评价了与二氧化钛（TiO 2）纳米颗粒的非氧化钛（TiO 2）纳米颗粒的生物机和生物学效应。注入TiO 2，UNC或盐水溶液。 6个月后，血液，肺，肝脏和肾脏样品进行组织学分析。通过膜脂质氧化（硫酰氨磺酸反应性物质-TBARS），在肺和肝脏中评估反应性氧物质（超氧化物阴离子-O 2 2）的产生和抗氧化酶（超氧化物歧化酶-SOD，过氧化氢酶-CAT）的产生。组织学观察在研究器官的实质中显示出TiO 2或Unc的凝聚，尽管没有比TiO 2沉积物更少。此外，TiO 2引起了肝脏和肾透明圆柱体中的坏死焦点的焦点。关于UNC值，在肺或肝脏样品中观察到酶损伤（TBARS）或酶促抗氧化剂的血液损伤。 O 2没有变化？在肺中观察到一代（CO：35.1？±±4.02与UNC; 48？±9.1，P？0.05）。相反，TiO 2曝光导致O 2的生产？在肺泡巨噬细胞和过氧化度酶的消耗中（P <0.05）。所研究的参数表明，UNCOD既没有生物化学也不导致组织学改变，因此可能被证明是用于生物医学植入物的表面涂层。还2016 Wiley期刊，Inc.J生物保解员B：Appl Biomater，105B：2408-2415,2017。

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