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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Morphological examination of highly porous polylactic acid/ B B ioglass ? ? scaffolds produced via nonsolvent induced phase separation
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Morphological examination of highly porous polylactic acid/ B B ioglass ? ? scaffolds produced via nonsolvent induced phase separation

机译：高度多孔聚乳酸/ B B碘糖的形态学检查？ 还 通过非溶剂诱导的相分离产生的支架

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Abstract In this study, we produce highly porous (up to ～91%) composite scaffolds of polylactic acid (PLA) containing 2 wt % sol‐gel‐derived 45S5 Bioglass ? particles via nonsolvent induced phase separation at ?23°C with no sacrificial phases involved. Before the incorporation of the bioglass with PLA, the particles are surface modified with a silane coupling agent which effectively diminishes agglomeration between them leading to a better dispersion of bioactive particles throughout the scaffold. Interestingly, the incorporation route (via solvent dichloromethane or nonsolvent hexane) of the surface modified particles in the foaming process has the greatest impact on porosity, crystallinity, and morphology of the scaffolds. The composite scaffolds with a morphology consisting of both mesopores and large macropores, which is potentially beneficial for bone regeneration applications, are examined further. SEM images show that the surface modified bioglass particles take‐up a unique configuration within the mesoporous structure of these scaffolds ensuring that the particles are well interlocked but not completely covered by PLA such that they can be in contact with physiological fluids. The results of preliminary in vitro tests confirm that this PLA/bioglass configuration promotes the interaction of the bioactive phase with physiological fluids. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2433–2442, 2017.
机译：摘要在这项研究中，我们生产高度多孔（高达〜91％）复合支架的聚乳酸（PLA）含有2wt％溶胶 - 凝胶衍生的45s5生物胶剂？通过非olvent诱导的相分离在α2℃下颗粒，没有涉及牺牲阶段。在用PLA掺入BioGlass之前，颗粒用硅烷偶联剂进行表面改性，其有效地减小它们之间的附聚，导致在整个支架中更好地分散生物活性颗粒。有趣的是，发泡过程中表面改性颗粒的掺入途径（通过溶剂二氯甲烷或非溶剂己烷）对支架的孔隙率，结晶度和形态产生最大的影响。进一步检查具有由中孔和大型大孔的形态的复合支架，其可能是对骨再生应用的潜在有益的影响。 SEM图像表明，表面改性的生物胶质颗粒在这些支架的中孔结构中占据了独特的配置，确保颗粒是良好的互锁，但不完全被PLA覆盖，使得它们可以与生理流体接触。初步体外试验结果证实，该PLA /生物糖类构型促进生物活性相与生理流体的相互作用。还2016 Wiley期刊，Inc .J生物保解率B部分：Appl Biomater，105B：2433-2442,2017。

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