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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >A silicone fiber coating as approach for the reduction of fibroblast growth on implant electrodes
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A silicone fiber coating as approach for the reduction of fibroblast growth on implant electrodes

机译：硅氧烷纤维涂层作为降低植入物电极成纤维细胞生长的方法

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Abstract In cochlear implant (CI) patients, an increase in electrode impedance due to fibrotic encapsulation is frequently observed. Several attempts have been proposed to reduce fibroblast growth at the electrode contacts, but none proved to be satisfactory so far. Here, a silicone fiber coating of the electrode contacts is presented that provides a complex micro‐scale surface topography and increases hydrophobicity to inhibit fibroblast growth and adhesion. A silicone fiber electrospinning process was developed to create a thin and porous fiber mesh. Fiber coatings were applied on graphite specimen holders, glass cover slips and CI electrode contacts. For characterization of the coating's pore distribution, water contact angle and electrical impedance were analyzed. Cytotoxicity and in vitro fibroblast growth were evaluated to assess biological efficacy of the coatings. It could be shown that the silicone fiber mesh itself had only minor influence on electrode impedance. A uniform, hydrophobic fiber coating could be achieved that decreased fibroblast growth without showing toxic effects. Finally, CI electrode contacts were successfully coated in order to present this promising approach for a long‐term improvement of CI electrodes. We are one of the first groups that could successfully adapt the electrospinning technique on the utilization of silicone. Silicone was chosen because of its high hydrophobicity, chemical stability and excellent biocompatibility and as it is one of the biomaterials already used in CIs. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2574–2580, 2017.
机译：摘要在耳蜗植入物（CI）患者中，经常观察到由于纤维化封装引起的电极阻抗的增加。已经提出了几次尝试减少电极触点处的成纤维细胞生长，但到目前为止没有证明是令人满意的。这里，提出了一种电极触点的有机硅纤维涂层，其提供复杂的微级表面形貌并增加疏水性以抑制成纤维细胞生长和粘合性。开发了硅氧烷纤维静电纺丝工艺以产生薄型和多孔的纤维网。玻璃盖板和CI电极触点施加纤维涂层。为了表征涂层的孔分布，分析了水接触角和电阻抗。评价细胞毒性和体外成纤维细胞生长以评估涂层的生物学效果。可以表明，硅氧烷纤维网本身对电极阻抗仅有微小的影响。可以实现均匀的疏水纤维涂层，其降低成纤维细胞生长而不显示出毒性作用。最后，成功地涂覆了CI电极触点，以提出这种有希望的CI电极的长期改善方法。我们是可以成功适应硅氧烷的静电纺丝技术的第一组之一。选择了硅胶，因为其高疏水性，化学稳定性和优异的生物相容性，并且它是已在顺式中使用的生物材料之一。还2016年Wiley期刊，Inc。J生物保解率B：Appl Biomater，105B：2574-2580,2017。

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