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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Effect of osteoporosis on fixation of osseointegrated implants in rats
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Effect of osteoporosis on fixation of osseointegrated implants in rats

机译：骨质疏松症对大鼠骨整合植入物固氮的影响

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Abstract The effect of osteoporosis on implant osseointegration has been widely investigated, whereas osteoporosis may also newly occur in patient with previously osseointegrated implant. This study was designed to investigate the effect of osteoporosis on implant fixation in rats after successful osseointegration had been obtained. Seventy female Sprague‐Dawley rats were included, and each animal received two titanium implants in the distal metaphysis of femur bilaterally. Eight weeks later, ten rats were sacrificed to confirm the establishment of implant osseointegration. All left rats were randomly subjected to bilateral ovariectomy (OVX) or sham operation. Three, six, and twelve weeks later, implant osseointegration, peri‐implant bone tissue, and biomechanical properties of implant were analyzed. Right femurs with implants were used for micro‐CT and histological analysis, and left femurs with implants were used for biomechanical test. Micro‐CT, histology, and biomechanical test confirmed the destructive effect of OVX on previously osseointegrated implant in rats; when compared to sham‐operated rats, peri‐implant bone volume, trabecular architecture, bone‐to‐implant contact ratio, as well as biomechanical parameters decreased progressively within 12 weeks. Results also indicated that the effect of OVX on undisturbed bone (proximal tibiae) was much stronger than that on peri‐implant bone. Osteoporosis produced a progressive negative effect on previously osseointegrated implant in distal femora of rats during 12 weeks. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2426–2432, 2017.
机译：摘要骨质疏松症对植入物骨整合的影响已被广泛研究，而骨质疏松症也可能在患有先前骨整合植入物的患者中新发生。本研究旨在探讨骨质疏松症对在获得成功骨整合后大鼠植入物固定的影响。包括七十个雌性Sprague-Dawley大鼠，每只动物在双侧股骨的远端复合中接受了两种钛植入物。八周后，处死十只大鼠以确认建立植入物骨整合。所有左转鼠都随机进行双侧卵巢切除术（OVX）或假手术。分析了三个，六个和12周后，分析了植入骨整合，植入物的植入骨组织和生物力学性质。使用植入物的右股骨用于微型CT和组织学分析，并使用植入物的血管用于生物力学测试。微型CT，组织学和生物力学测试证实了OVX在预先对大鼠骨整合植入物上的破坏性作用;与假手术大鼠，Peri-incormant骨骼体积，小梁架构，骨对植入的接触比相比，以及生物力学参数在12周内逐渐降低。结果还表明，OVX对未受干扰的骨骼（近端胫骨）的影响比Peri植入骨骼更强烈。骨质疏松症在12周内对大鼠远端股骨的前骨整合植入物产生了逐渐消极影响。还2016 Wiley期刊，Inc。J生物保解员B部分B：苹果生物检索物，105B：2426-2432，2017。

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