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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Does cefuroxime alter fracture healing in vivo in vivo ? A micro‐computertomographic, biomechanical, and histomorphometric evaluation using a rat fracture model
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Does cefuroxime alter fracture healing in vivo in vivo ? A micro‐computertomographic, biomechanical, and histomorphometric evaluation using a rat fracture model

机译：头孢呋辛是否在体内改变体内骨折愈合？ 使用大鼠裂缝模型进行微型计算，生物力学和组织形态学评估

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Abstract Cefuroxime is widely used for antibiotic prophylaxis in orthopedic surgery. However, a recent study indicated a dose‐dependent reduction in osteoblast function in vitro . Nevertheless, cell culture might not sufficiently imitate the complex process of bone remodeling. As data concerning possible in vivo interactions of cefuroxime on fracture healing are completely missing, we investigated the following hypothesis: Does Cefuroxime impair bone healing in vivo ? Therefore, 34 male Wistar rats were randomised to cefuroxime‐treated or control groups, a Kirschner wire was inserted into right femora and closed transverse fractures were produced. Twenty‐one days later, the structural properties of the fracture callus in the early fracture healing phase were evaluated via a combination of micro‐CT (μCT), biomechanics and histology. μCT demonstrated similar values in the cefuroxime and control group (e.g., callus volume: 67.19?±?14.90 mm 3 vs. 55.35?±?6.74 mm 3 , p ?=?0.12; density: 635.48?±?14.81 mg HA/cm 3 vs. 647.87?±?13.01 mg HA/cm 3 , p ?=?0.16). Biomechanically, similar values were again determined between the groups, in terms of both maximum load (77.65?±?41.82 vs. 78.54?±?20.52, p ?=?0.95) and stiffness (122.44?±?81.16 vs. 123.74?±?60.08, p ?=?0.97). Histological findings were consistent with the radiographic results. Thus, no relevant differences between the cefuroxime and control groups could be found and the reported negative effects on osteoblasts in vitro were not confirmed in vivo by using standard concentrations of cefuroxime. In conclusion, cefuroxime can reasonably be recommended in a clinical setting as an antibiotic therapy when fracture healing is involved. However, supraphysiological doses were not evaluated, which may be present when cefuroxime is used as an additive to bone cement and released over time. Therefore, future studies should evaluate the in vivo effects of prolonged high cefuroxime doses on implant incorporation. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2282–2291, 2017.
机译：摘要Cefuroxime广泛用于整形外科手术中的抗生素预防。然而，最近的一项研究表明体外骨质细胞功能的剂量依赖性降低。然而，细胞培养可能无法充分模仿骨重塑的复杂过程。随着Cefuroxime对骨折愈合的细胞毒性相互作用的数据完全缺失，我们调查了以下假设：头孢呋辛是否损害体内骨愈合？因此，将34只雄性Wistar大鼠随机化为头孢呋辛处理或对照组，将Kirschner线插入右股骨，并产生闭合横向骨折。二十一天后，通过微型CT（μCT），生物力学和组织学的组合评估早期骨折愈合相中骨折愈伤组织的结构性质。 μct在头孢呋辛和对照组中展示了类似的值（例如，愈伤组织体积：67.19？±±14.90mm 3与55.35？±6.74 mm 3，p？= 0.12;密度：635.48？±14.81 mg ha / cm 3与647.87？±13.01 mg ha / cm 3，p？= 0.16）。生物力学，在最大载荷方面，在组之间再次确定类似的值（77.65？±41.82 vs.78.54？±20.52，p？= 0.95）和刚度（122.44？±81.16与123.74？± ？60.08，p？=？0.97）。组织学发现与放射线摄影结果一致。因此，可以发现头孢呋辛和对照组之间没有相关的差异，并且通过使用标准浓度的头孢呋肟在体内证实了对体外成骨细胞的报告的负面影响。总之，当涉及骨折愈合时，可以合理地推荐在临床环境中合理地建议使用临床环境。然而，不评估递增剂量的剂量，当Cefuroxime用作骨水泥和随时间释放的添加剂时，可能存在。因此，未来的研究应评估长期高小头孢藤肟剂量对植入物掺入的体内效应。还2016 Wiley期刊，Inc.J生物保解员B部分B：Appl Biomater，105B：2282-2291,2017。

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