• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Validation and application of a nondestructive and contactless method for rheological evaluation of biomaterials
【24h】

Validation and application of a nondestructive and contactless method for rheological evaluation of biomaterials

机译：非破坏性和非接触式方法对生物材料流变评估的验证与应用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Hydrogels are extensively used for tissue engineering, cell therapy or controlled release of bioactive factors. Nondestructive techniques that can follow their viscoelastic properties during polymerization, remodeling, and degradation are needed, since these properties are determinant for their in vivo efficiency. In this work, we proposed the viscoelastic testing of bilayered materials (VeTBiM) as a new method for nondestructive and contact‐less mechanical characterization of soft materials. The VeTBiM method measures the dynamic displacement response of a material, to a low amplitude vibration in order to characterize its viscoelastic properties. We validated VeTBiM by comparing data obtained on various agar and chitosan hydrogels with data from rotational rheometry, and compression tests. We then investigated its potential to follow the mechanical properties of chitosan hydrogels during gelation and in the presence of papain and lysozyme that induce fast or slow enzymatic degradation. Due to this nondestructive and contactless approach, samples can be removed from the instrument and stored in different conditions between measurements. VeTBiM is well adapted to follow biomaterials alone or with cells, over long periods of time. This new method will help in the fine tuning of the mechanical properties of biomaterials used for cell therapy and tissue engineering. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2565–2573, 2017.
机译：摘要水凝胶广泛用于组织工程，细胞疗法或受控释放生物活性因子。需要在聚合，重塑和降解期间遵循其粘弹性的无损技术，因为这些性质是体内效率的决定因素。在这项工作中，我们提出了双层材料（VETBIM）的粘弹性测试，作为软材料的非破坏性和接触机械表征的新方法。 VETBIM方法测量材料的动态位移响应，以表征其粘弹性的粘弹性。通过将在各种琼脂和壳聚糖水凝胶上获得的数据与来自旋转流变学的数据和压缩测试进行比较，我们通过验证了vetbim。然后，我们研究了凝胶化在凝胶化水凝胶的机械性能和蛋白质和溶菌酶的存在下遵循壳聚糖水凝胶的潜力。由于这种无损和非接触的方法，可以从仪器中取出样品并在测量之间储存在不同的条件下。 Vetbim很好地适应单独或用细胞遵循生物材料，长时间。这种新方法将有助于微调用于细胞疗法和组织工程的生物材料的机械性能。还2016 Wiley期刊，INC.J生物保解员B部分B：苹果生物摩特，105B：2565-2573，2017。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号