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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Analysis of the application of the generalized monod kinetics model to describe the human corneal oxygen‐consumption rate during soft contact lens wear
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Analysis of the application of the generalized monod kinetics model to describe the human corneal oxygen‐consumption rate during soft contact lens wear

机译：广义Monod动力学模型应用柔软隐形眼镜磨损期间描述人角膜氧消耗率的应用

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Abstract This work is an analysis of the application of the generalized Monod kinetics model describing human corneal oxygen consumption during soft contact lens wear to models previously used by Chhabra et al. (J Biomed Mater Res B Appl Biomater, 2009a;90:202‐209, Optom Vis Sci 2009b;86:454‐466) and Larrea and Büchler (Invest Ophthalmol Vis Sci 2009;50:1076‐1080). We use oxygen tension from in vivo estimations provided by Bonanno [Bonanno et al., Invest Ophthalmol Vis Sci 2002;43:371‐376, and Bonanno et al 2009]. We consider four hydrogel and six silicone hydrogel lenses. The cornea is considered a single homogeneous layer, with constant oxygen permeability regardless of the type of lens worn. Our calculations yield different values for the maximum oxygen consumption rate Q c,max , whith differents oxygen tensions (high and low p c ) at the cornea‐tears interface. Surprisingly, for both models, we observe an increase in oxygen consumption near an oxygen tension of 105 mmHg until a maximum is reached, then decreasing for higher levels of oxygen pressure. That is, when lowering the pressure of oxygen, the parameter Q c,max initially increases depending on the intensity of the change in pressure. Which, it could be related with the variation of the pH. Furthermore, it is also noted that to greater reductions in pressure, this parameter decreases, possibly due to changes in the concentration of glucose related to the anaerobic respiration. The averaged in vivo human corneal oxygen consumption rate of 1.47 × 10 ?4 cm 3 of O 2 /cm 3 tissue s , with Monod kinetics model, considering all the lenses studied, is smaller than the average oxygen consumption rate value obtained using the Larrea and Büchler model. The impact that these calculations have on the oxygen partial pressure available at different depths in the corneal tissue is presented and discussed, taking into consideration previous models used in this study. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2269–2281, 2017.
机译：摘要这项工作是对描述在柔软的隐形眼镜磨损期间，将描述人角膜氧气消耗的广义Monod动力学模型的应用分析。 （J生物密修res B申请Bimomater，2009A; 90：202-209，OPTOM VIS 2009B; 86：454-466）和Larrea和Büchler（Invest Ophthalmol Vis 2009; 50：1076-1080）。我们在Bonanno提供的体内估计中使用氧气张力[Bonanno等，Invest Ophthalmol Vis Sci 2002; 43：371-376和Bonanno等，2009]。我们考虑四个水凝胶和六个有机硅水凝胶镜片。角膜被认为是单一的均匀层，无论佩戴的镜片类型如何，都具有恒定的透氧性。我们的计算产生了不同的氧气消耗率Q C，MAX，WHITH在角膜撕裂界面处的氧气张力（高低P C）的不同值。令人惊讶的是，对于这两种模型，我们观察到氧气消耗的增加在105mmHg的氧气张力附近，直到达到最大值，然后降低较高水平的氧气压力。也就是说，当降低氧气的压力时，参数Q C，Max最初根据压力变化的强度而增加。它可以与pH的变异有关。此外，还注意到，在压力下减少，该参数降低，可能是由于与厌氧呼吸有关的葡萄糖浓度的变化。体内人体角膜氧消耗率的平均为1.47×10？4 cm 3的O 2 / cm 3组织S，考虑到所研究的所有镜片，小于使用兰雷获得的平均氧气消耗率值小于和büchler模型。介绍并讨论了这些计算对不同深度可用的氧分压的影响，并考虑了本研究中使用的以前的模型。还2016 Wiley期刊，INC.J生物保解员B部分B：Appl Biomater，105B：2269-2281,2017。

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