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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Non‐invasive monitoring of branched Au nanoparticle‐mediated photothermal ablation
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Non‐invasive monitoring of branched Au nanoparticle‐mediated photothermal ablation

机译：支链Au纳米粒子介导的光热消融的非侵入性监测

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Abstract Nanoparticle‐mediated photothermal therapy for treatment of different types of tumors has attracted tremendous attention in recent years. One major factor that drives this therapy is the ability to carefully control and prevent inadvertent damage to local tissues, while focusing therapeutic heating to specific regions of the tumor tissues. To this end, it is critical to generate efficient heating in the targeted tumors while monitoring the extent and distribution of heating. In our study, we demonstrated the photothermal heating properties of our synthesized branched Au nanoparticles (b‐AuNPs) using non‐invasive MR thermometry (MRT) techniques to assess its effects both in vitro and in vivo . 75 nm b‐AuNPs were synthesized; these b‐AuNPs demonstrated strong near infrared (NIR) absorption and high heat transducing efficiency. Proton resonance frequency MRT approaches for monitoring b‐AuNPs mediated heating were validated using in vitro agar phantoms and further evaluated during in vivo animal model tumor ablation studies. In vitro phantom studies demonstrated a strong linear correlation between MRT and reference‐standard thermocouple measurements of b‐AuNPs‐mediated heating upon NIR laser irradiation; temperatures increased with both an increase in laser power and increased exposure duration. Localized photothermal heating in regions containing the b‐AuNPs was confirmed through MRT generated temperature maps acquired serially at increasing depths during both phantom and in vivo studies. Our results suggested that b‐AuNPs exposed to NIR radiation produced highly efficient localized heating that can be accurately monitored dynamically using non‐invasive MRT measurements. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2352–2359, 2017.
机译：摘要近年来，纳米粒子介导的用于治疗不同类型肿瘤的光热疗。驱动这种治疗的一个主要因素是能够仔细控制和预防对局部组织的无意损害，同时将治疗性加热聚焦到肿瘤组织的特定区域。为此，在监测加热程度和分配的同时在靶向肿瘤中产生有效的加热至关重要。在我们的研究中，我们证明了使用非侵入性MR温度（MRT）技术的合成支链Au纳米颗粒（B-AUNP）的光热加热特性，以评估体外和体内的影响。合成75 nm B-aUnps;这些B-AUNPS在近红外（NIR）吸收和高热转换效率方面呈现出强大的近红外线（NIR）。用于监测B-AUNPS介导的加热的质子共振频率MRT方法使用体外琼脂映像进行验证，并在体内动物模型肿瘤消融研究中进一步评估。体外幻影研究表明，在NIR激光照射时B-AUNPS介导的B-AUNPS介导的加热的MRT和参考标准热电偶测量的强烈线性相关性;温度随着激光功率的增加和曝光持续时间而增加。通过在脉体和体内研究期间串联延长的MRT产生的温度图确认含有B-AUNP的区域中的局部光热加热。我们的研究结果表明，暴露于NIR辐射的B-AUNP产生高效的局部加热，可以使用非侵入式MRT测量动态地进行精确监测。还2016 Wiley期刊，Inc。J生物保解率B部分：Appl Biomater，105B：2352-2359,2017。

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