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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >The design and fabrication of a three‐dimensional bioengineered open ventricle
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The design and fabrication of a three‐dimensional bioengineered open ventricle

机译：三维生物工程公开心室的设计和制作

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Abstract Current treatments in hypoplastic left heart syndrome (HLHS) include multiple surgeries to refunctionalize the right ventricle and/or transplant. The development of a tissue‐engineered left ventricle (LV) would provide a therapeutic option to overcome the inefficiencies and limitations associated with current treatment options. This study provides a foundation for the development and fabrication of the bioengineered open ventricle (BEOV) model. BEOV molds were developed to emulate the human LV geometry; molds were used to produce chitosan scaffolds. BEOV were fabricated by culturing 30 million rat neonatal cardiac cells on the chitosan scaffold. The model demonstrated 57% cell retention following 4days culture. The average biopotential output for the model was 1615 μV. Histological assessment displayed the presence of localized cell clusters, with intercellular and cell‐scaffold interactions. The BEOV provides a novel foundation for the development of a 3D bioengineered LV for application in HLHS. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2206–2217, 2017.
机译：摘要左心综合征（HLHS）中的目前治疗包括多种手术，以重新核化右心室和/或移植。组织工程左心室（LV）的发展将提供治疗选择，以克服与当前治疗方案相关的低效率和限制。本研究为生物工程的开放性心室（B​​EOV）模型的开发和制作提供了基础。 Beov模具被开发出来模仿人LV几何形状;模具用于生产壳聚糖支架。 Beov是通过在壳聚糖支架上培养3000万只大鼠新生儿心脏细胞而制造的。该模型在第4天文化后展示了57％的细胞保留。该模型的平均双向输出为1615μV。组织学评估显示局部细胞簇的存在，细胞间和细胞支架相互作用。 BEOV为在HLHS中施用3D生物工程LV提供了一种新的基础。还2016 Wiley期刊，INC.J生物保解员A型B：苹果生物摩特，105B：2206-2217，2017。

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