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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >pH and metal concentration of synovial fluid of osteoarthritic joints and joints with metal replacements
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pH and metal concentration of synovial fluid of osteoarthritic joints and joints with metal replacements

机译：骨关节关节和金属替代接头的滑液和金属浓度

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Abstract Background : Due to degradation and metal dissolution during articulation of metal joint replacements the chemical periprosthetic environment may change. The aim was to establish whether metal replacements cause the local changes in pH and elevated metal concentrations. Methods : pH was measured on samples from 167 patients: native hip and knee osteoarthritic joints, joints with hip and knee replacements revised for aseptic or septic reasons. pH of synovial fluid and periprosthetic tissue was measured perioperatively using a microelectrode and pH indicator papers for removed metal components. Metal concentrations were measured in 21 samples using inductively coupled plasma mass spectrometry. Results : The mean pH value of synovial fluid at native osteoarthritic joints ( n ?=?101) was 7.78?±?0.38. The mean pH value of synovial fluid at revision aseptic operation ( n ?=?58) was 7.60?±?0.31, with statistically significant difference ( p ?=?0.002) compared to native osteoarthritic joints. The mean pH value of synovial fluid at revision septic operation ( n ?=?8) was 7.55?±?0.25, with statistically significant difference ( p ?=?0.038) compared to native osteoarthritic joints. Measurements in tissue and at stems were not reliable. In the majority of samples taken at revision increased levels of cobalt and chromium were measured. Conclusion : A small but statistically significant difference was observed in the pH of synovial fluid between natural joints with degenerative diseases and joints treated with metal replacements. Based on the increased metal levels we expected the value of pH to be lower, but the influence of metal ions is counteracted by the buffering capacity of human body. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2507–2515, 2017.
机译：摘要背景：由于金属关节置换铰接期间的降解和金属溶解，化学危险环境可能会发生变化。目的是建立金属替代品是否导致局部的pH和升高的金属浓度变化。方法：从167名患者的样品上测量pH值：天然髋关节和膝关节骨关节，髋关节和膝关节的关节修订，无菌或脓毒症原因修订。使用微电极和pH指示剂仔细测量外膜流体和Periprosthetth组织的pH，用于除去金属组分。使用电感耦合等离子体质谱法在21个样品中测量金属浓度。结果：天然骨关节关节滑膜液的平均pH值（n？= 101）为7.78≤0.38。在修改无菌操作（n？=Δ58）下滑动液的平均pH值为7.60？±0.31，与天然骨关节关节相比，统计学上有显着差异（p？= 0.002）。在修改脓化物理（n？=Δ8）下滑动液的平均pH值为7.55？±0.25，与本地骨关节关节相比，具有统计学上显着的差异（p？= 0.038）。在组织和茎中的测量不可靠。在修正的大多数样品中，测量了钴和铬水平的增加。结论：在用金属替代品处理的天然关节与结合疾病和接头的滑膜液的pH中观察到小但统计学显着差异。基于增加的金属水平，我们预期pH值的值降低，但是金属离子的影响因人体的缓冲能力而抵消。还2016 Wiley期刊，Inc.J生物保解员B部分B：苹果生物摩特，105B：2507-2515,2017。

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