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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >3D perfusion bioreactor‐activated porous granules on implant fixation and early bone formation in sheep
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3D perfusion bioreactor‐activated porous granules on implant fixation and early bone formation in sheep

机译：3D灌注生物反应器 - 活化多孔颗粒对绵羊植入固定和早期骨形成的植入物固定

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Abstract Early fixation of total joint arthroplasties is crucial for ensuring implant survival. An alternative bone graft material in revision surgery is needed to replace the current gold standard, allograft, seeing that the latter is associated with several disadvantages. The incubation of such a construct in a perfusion bioreactor has been shown to produce viable bone graft materials. This study aimed at producing larger amounts of viable bone graft material (hydroxyapatite 70% and β‐tricalcium‐phosphate 30%) in a novel perfusion bioreactor. The abilities of the bioreactor‐activated graft material to induce early implant fixation were tested in a bilateral implant defect model in sheep, with allograft as the control group. Defects were bilaterally created in the distal femurs of the animals, and titanium implants were inserted. The concentric gaps around the implants were randomly filled with either allograft, granules, granules with bone marrow aspirate or bioreactor‐activated graft material. Following an observation time of 6 weeks, early implant fixation and bone formation were assessed by micro‐CT scanning, mechanical testing, and histomorphometry. Bone formations were seen in all groups, while no significant differences between groups were found regarding early implant fixation. The microarchitecture of the bone formed by the synthetic graft materials resembled that of allograft. Histomorphometry revealed that allograft induced significantly more bone and less fibrous tissue ( p ??0.05). In conclusion, bone formation was observed in all groups, while the bioreactor‐activated graft material did not reveal additional effects on early implant fixation comparable to allograft in this model. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2465–2476, 2017.
机译：摘要总关节关节塑料的早期固定对于确保植入物存活至关重要。需要修订手术中的替代骨移植材料来取代当前的金标准，同种异体移植物，从而看到后者与几个缺点相关。已经示出了在灌注生物反应器中孵育这种构建体，以产生活性骨接枝材料。该研究旨在在新型灌注生物反应器中产生较少量的活骨移植物质（羟基磷灰石70％和β-三磷酸钙30％）。生物反应器激活的接枝材料的能力在绵羊的双侧植入物缺陷模型中测试了早期植入物固定的，用同种异体移植为对照组。缺陷在动物的远端股骨中是双侧产生的，并且插入钛植入物。植入物周围的同心差距被随机填充有同种异体移植物，颗粒，颗粒，颗粒骨髓吸气或生物反应器活化接枝材料。在6周的观察时间之后，通过微CT扫描，机械测试和组织形态评估早期植入固定和骨形成。在所有组中看到骨骼形成，而在早期植入物固定中发现组之间没有显着差异。由合成接枝材料形成的骨骼的微体系结构类似于同种异体移植物的骨骼。组织形态学揭示了同种异体移植诱导的骨骼和较少的纤维组织（p≤≤0.05）。总之，在所有组中观察到骨形成，而生物反应器活化的接枝材料未透露与该模型中同种异体移植相当的早期植入物固定的额外影响。还2016 Wiley期刊，Inc.J生物保证金Mater Res B：Appl Biomater，105B：2465-2476,2017。

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