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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Sol–gel derived bioactive coating on zirconia: Effect on flexural strength and cell proliferation
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Sol–gel derived bioactive coating on zirconia: Effect on flexural strength and cell proliferation

机译：溶胶 - 凝胶在氧化锆上衍生的生物活性涂层：对弯曲强度和细胞增殖的影响

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Abstract The purpose of this study was to evaluate the effect of sol–gel derived bioactive coatings on the biaxial flexural strength and fibroblast proliferation of zirconia, aimed to be used as an implant abutment material. Yttrium stabilized zirconia disc‐shaped specimens were cut, ground, sintered, and finally cleansed ultrasonically in each of acetone and ethanol for 5 minutes. Three experimental groups ( n ?=?15) were fabricated, zirconia with sol–gel derived titania (TiO 2 ) coating, zirconia with sol–gel derived zirconia (ZrO 2 ) coating, and non‐coated zirconia as a control. The surfaces of the specimens were analyzed through images taken using a scanning electron microscope (SEM), and a non‐contact tapping mode atomic force microscope (AFM) was used to record the surface topography and roughness of the coated specimens. Biaxial flexural strength values were determined using the piston‐on‐three ball technique. Human gingival fibroblast proliferation on the surface of the specimens was evaluated using AlamarBlue assay?. Data were analyzed using a one‐way analysis of variance (ANOVA) followed by Tukey's post‐hoc test. Additionally, the biaxial flexural strength data was also statistically analyzed with the Weibull distribution. The biaxial flexural strength of zirconia specimens was unaffected ( p ??0.05). Weibull modulus of TiO 2 coated and ZrO 2 coated groups (5.7 and 5.4, respectively) were lower than the control (8.0). Specimens coated with ZrO 2 showed significantly lower fibroblast proliferation compared to other groups ( p ??0.05). In conclusion, sol–gel derived coatings have no influence on the flexural strength of zirconia. ZrO 2 coated specimens showed significantly lower cell proliferation after 12 days than TiO 2 coated or non‐coated control. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2401–2407, 2017.
机译：摘要本研究的目的是评估溶胶 - 凝胶衍生的生物活性涂层对氧化锆的双轴弯曲强度和成纤维细胞增殖的影响，目的是用作植入式邻接材料。钇稳定的氧化锆盘形样品被切割，研磨，烧结，并最终在丙酮和乙醇中的每一个中超声擦拭5分钟。制造了三个实验组（N？=α15），氧化锆配溶胶 - 凝胶衍生的二氧化钛（TiO 2）涂布，氧化锆，氧化锆衍生的氧化锆（ZrO 2）涂布，以及非涂覆的氧化锆作为对照。通过使用扫描电子显微镜（SEM）拍摄的图像分析样品的表面，并且使用非接触式攻丝模式原子力显微镜（AFM）来记录涂层样本的表面形貌和粗糙度。使用活塞对三个球技术测定双轴弯曲强度值。使用Alamarblue测定评估样品表面上的人牙龈成纤维细胞增殖α。使用单向分析的差异（ANOVA）进行分析数据，然后是Tukey的Hoc测试。另外，双轴弯曲强度数据也用Weibull分布统计学分析。氧化锆标本的双轴弯曲强度不受影响（p？＆β05）。 TiO 2涂覆和ZrO 2涂覆基团（分别分别为5.7和5.4分别）的Weibull模量低于对照（8.0）。与其他基团相比，涂有ZrO 2的试样显着降低成纤维细胞增殖（p≤≤0.05）。总之，溶胶 - 凝胶衍生的涂层对氧化锆的抗弯强度没有影响。 ZrO 2涂层标本在12天后显示比TiO 2涂覆或非涂覆的对照显着降低细胞增殖。还2016 Wiley期刊，Inc.J生物保解率B部分B：苹果生物摩特，105B：2401-2407，2017。

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