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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Degradation and biocompatibility of photoembossed PLGA-acrylate blend for improved cell adhesion
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Degradation and biocompatibility of photoembossed PLGA-acrylate blend for improved cell adhesion

机译：光血杂交PLGA - 丙烯酸酯混合物的降解和生物相容性，提高细胞粘附性

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We have shown previously that PMMA-acrylate photopolymers are biocomopatible and can exhibit improved cell adhesion compared to PMMA, due to an increase in negative surface charge caused by UV radiation PLGA has been used widely in soft tissue regeneration due to its high biocompatibility and cell adhesion. This polymer is also biodegradable and can be utilised in the field of vascular regeneration. In this study, PLGA is blended with a triacrylate monomer (TPETA) to create a degradable photopolymer blend. Surface relief structures are formed on this PLGA-TPETA by photoembossing. An optimum height of 950 nm was achieved for a 10 mu m pitch with the height of these relief structures being controlled by changing UV intensity, processing temperature and time. Degradation studies of this blend revealed a bulk degradation mechanism with PLGA-TPETA degrading slower compared to pure PLGA. We also evaluated the adhesion of human umbilical vein endothelial cells (HUVECs) on both smooth and textured PLGA-TPETA films. Embossed PLGA-TPETA films showed improved cell adhesion compared to smooth substrates. Furthermore, HUVECs proliferated faster on the embossed surface compared to their smooth counterparts. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 163-171, 2018.
机译：我们先前表明，与PMMA相比，PMMA-丙烯酸酯光聚合物是生物缺陷的并且可以表现出改善的电池粘附，由于由UV辐射PLGA引起的负面表面电荷的增加，由于其高生物相容性和细胞粘附，因此通过紫外线辐射PLGA被广泛使用的软组织再生。 。该聚合物也可生物降解，可用于血管再生领域。在该研究中，将PLGA与三丙烯酸酯单体（TPETA）混合以产生可降解的光聚合物共混物。表面浮雕结构通过光训练在该PLGA-TPETA上形成。通过通过改变UV强度，加工温度和时间来控制10μmμm间距，实现10μm的最佳高度为950nm。与纯PLGA相比，该混合物的降解研究揭示了具有PLGA-TPETA降低的大量降解机理。我们还评估了人脐静脉内皮细胞（HUVECS）对光滑和纹理PLGA-TPETA薄膜的粘附性。与光滑的基材相比，压花PLGA-TPETA薄膜显示出改善的电池粘附。此外，与光滑的对应物相比，Huvecs在压花表面上更快地增殖。 （c）2016 Wiley期刊，Inc。J生物保解员B：Appl Biomater，106B：163-171,2018。

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