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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Chitosan coatings with enhanced biostability in vivo
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Chitosan coatings with enhanced biostability in vivo

机译：壳聚糖涂层具有增强的生物稳定性体内

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In this article, we study the stability of chitosan coatings applied on glutaraldehyde-stabilized bovine pericardium when exposed to biodegradation in vivo in the course of model subcutaneous tests on rats. The coatings were deposited from carbonic acid solutions, that is, H2O saturated with CO2 at high pressure. Histological sections of treated pericardium samples demonstrated that the structure of pericardial connective tissues was not significantly altered by the coating application method. It was revealed that the dynamics of biodegradation depended on the total mass of chitosan applied as well as on the DDA of chitosan used. As long as the amount of chitosan did not exceed a certain threshold limit, no detectable degradation occurred within the time of the tests (12 weeks for the rat model). For higher chitosan amounts, we detected a approximate to 20% reduction of the mass after the in vivo exposition. The presumed mechanism of such behavior is discussed. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 270-277, 2018.
机译：在本文中，我们研究了在大鼠模型皮下试验过程中暴露于体内生物降解时，在谷氨酸稳定的牛心包上施用壳聚糖涂料的稳定性。将涂层从碳酸溶液中沉积，即，在高压下用CO 2饱和H 2 O。治疗的心包样品的组织学部分表明，涂料施加方法没有显着改变心包结缔组织的结构。据透露，生物降解的动态取决于壳聚糖的总质量以及壳聚糖的DDA。只要壳聚糖的量没有超过一定的阈值限制，在试验时没有发生可检测的降解（大鼠模型的12周）。对于高等壳聚糖量，我们检测到体内阐述后质量的20％近似。讨论了这种行为的假定机制。 （c）2017年Wiley期刊，Inc。J生物保解员B部分B：苹果生物检索物，106B：270-277,2018。

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