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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Lithium doped calcium phosphate cement maintains physical mechanical properties and promotes osteoblast proliferation and differentiation
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Lithium doped calcium phosphate cement maintains physical mechanical properties and promotes osteoblast proliferation and differentiation

机译：锂掺杂磷酸钙水泥保持物理机械性能并促进成骨细胞增殖和分化

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Abstract Calcium phosphate cement (CPC) has been widely used in bone tissue repairing due to its physical mechanical properties and biocompatibility. Addition of trace element to CPC has shown promising evidence to improve the physical properties and biological activities of CPC. Lithium (Li) has effect on osteoblast proliferation and differentiation. In this study, we incorporated Li to CPC and examined the physical properties of Li/CPC and its effect on osteoblast proliferation and differentiation. We found that Li doped CPC maintained similar setting time, pore size distribution, compressive strength, composition, and morphology as CPC without Li. Additionally, Li doped CPC improved osteoblast proliferation and differentiation significantly compared to CPC without Li. To our knowledge, our results, for the first time, show that Li doped CPC has beneficial effect on osteoblast in cell culture while keeps the excellent physical–mechanical properties of CPC. This study will lead to potential application of Li doped CPC in bone tissue engineering. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 944–952, 2017.
机译：摘要由于其物理机械性能和生物相容性，磷酸钙水泥（CPC）已广泛用于骨组织修复。向CPC添加痕量元素已显示有希望的证据，以改善CPC的物理性质和生物学活动。锂（Li）对成骨细胞增殖和分化具有影响。在这项研究中，我们纳入了李至CPC，并检查了Li / CPC的物理性质及其对成骨细胞增殖和分化的影响。我们发现李掺杂的CPC保持了类似的设定时间，孔径分布，抗压强度，组成和形态，因为没有LI。此外，李掺杂CPC改善了成骨细胞增殖和分化与CPC没有LI。据我们所知，我们的结果首次表明，李掺杂的CPC对细胞培养中的成骨细胞具有有益作用，同时保持CPC的优异物理机械性能。该研究将导致Li掺杂CPC在骨组织工程中的潜在应用。还2016 Wiley期刊，Inc .J生物保解率A件B：苹果生物检索物，105B：944-952，2017。

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