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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Substituted hydroxyapatites for bone regeneration: A review of current trends
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Substituted hydroxyapatites for bone regeneration: A review of current trends

机译：取代骨再生的羟基磷灰石：对当前趋势的综述

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Abstract At present hydroxyapatite (HA) is been extensively investigated for biomedical applications, largely as a result of its similarity in composition to the mineral portion of bone. Although HA undergoes osseointegration and is bioactive and osteoconductive, the inherent brittleness and low fracture toughness limits its use under load bearing conditions, also once implanted in the body, HA takes a long time to resorb. The crystal structure of HA is conducive to a variety of ionic substitutions. To accurately mimic the calcium deficient and carbonate‐containing nature of HA in bone, both cationic and anionic substituents have been incorporated to synthetic HA. This article focuses on the incorporation of both the well established (Zn, Si, Sr, F, and carbonate) and latest ions (Ag, citrate, iron, niobate, and tantalates) into the HA structure and aims to highlight the key effects of these substitutions in terms of their chemical, physical, and biological properties. It can be shown that a minor substituent cannot only alter the microstructure, stability and crystallinity of the HA structure in an implant, but also have a significant effect on bone cells colonizing the implant, which in turn can influence the new bone formation and bone remodeling processes. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1285–1299, 2017.
机译：摘要目前羟基磷灰石（HA）被广泛研究了生物医学应用，主要是由于其在骨骼矿物部分的组合物中的相似性。虽然HA经历骨整合并且是生物活性和骨导电的，但固有的脆性和低断裂韧性限制其在负载轴承条件下的使用，也曾经植入体内，但HA需要很长时间才能再次进行。 HA的晶体结构有利于各种离子取代。为了准确地模仿HA在骨中HA的含钙和碳酸盐性质，阳离子和阴离子取代基都已掺入合成HA。本文侧重于将成立良好的（Zn，Si，Sr，F和碳酸盐）和最新的离子（Ag，柠檬酸盐，铁，铌酸盐和钽）掺入HA结构中，并旨在突出这些关键效果这些替换在其化学品，物理和生物学性质方面。可以表明，次次取代基不能仅改变植入物中HA结构的微观结构，稳定性和结晶度，而且对植入物定植的骨细胞具有显着影响，这又可以影响新的骨形成和骨质重塑流程。还2016 Wiley期刊，Inc。J生物母乳部分B：苹果生物摩特，105B：1285-1299,2017。

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