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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Characterization and biological evaluation of the introduction of PLGA into biosilicate ? ?
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Characterization and biological evaluation of the introduction of PLGA into biosilicate ? ?

机译：将PLGA引入生物硅酸盐的特征及生物学评价？ 还

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Abstract The aims of this study were to characterize different BS/PLGA composites for their physicochemical and morphological characteristics and evaluate the in vitro and in vivo biological performance. The physicochemical and morphological modifications were analyzed by pH, mass loss, XRD, setting time, and SEM. For in vitro analysis, the osteoblast and fibroblast viability was evaluated. For in vivo evaluations, histopathology and immunohistochemistry were performed in a tibial defect in rats. After incubation, all composites presented lower values in pH and mass loss over time. Moreover, XRD and SEM analysis confirmed that the composites degraded over time. Additionally, pore formation was observed by SEM analysis after incubation mainly in BS/PLGA groups. BS/PLGA showed significantly increased in osteoblast viability 24 h. Moreover, BS/PLGA composites demonstrated an increase in fibroblast viability in all periods analyzed when compared to BS. In the in vivo study, after 2 and 6 weeks of implantation of biomaterials, histopathological findings revealed that the BS/PLGA composites degrades over time, mainly at periphery. Moreover, can be observed the presence of granulation tissue, bone formation, Runx‐2, and RANKL immunoexpression in all groups. In conclusion, BS/PLGA composites present appropriate physicochemical characteristics, stimulate the cellular viability, and enhance the bone repair in vivo . ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1063–1074, 2017.
机译：摘要本研究的目的是表征不同的BS / PLGA复合材料，用于其物理化学和形态特征，并评估体外和体内生物学性能。通过pH，质量损失，XRD，凝固时间和SEM分析物理化学和形态学修饰。对于体外分析，评估成骨细胞和成纤维细胞活力。对于体内评价，组织病理学和免疫组织化学在大鼠的胫骨缺陷中进行。孵育后，所有复合材料随时间呈现较低的pH值和质量损失。此外，XRD和SEM分析证实复合材料随时间劣化。另外，通过主要在BS / PLGA组孵育后通过SEM分析观察到孔形成。 BS / PLGA显示出在24小时的成骨细胞活力明显增加。此外，BS / PLGA复合材料在与BS相比，在分析的所有时期中表明成纤维细胞活力增加。在体内研究中，在植入生物材料的2和6周后，组织病理学发现表明，BS / PLGA复合材料随时间劣化，主要是周边。此外，可以观察到肉芽组织，骨形成，runx-2和所有组中的RANKL免疫表达的存在。总之，BS / PLGA复合材料具有适当的物理化学特性，刺激细胞活力，并增强体内骨骼修复。还2016 Wiley期刊，Inc.J生物保解率B部分：Appl Biomater，105B：1063-1074,2017。

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    Fernandes K. R.; Magri A. M. P.; Kido H. W.; Ueno F.; Assis L.; Fernandes K. P. S.; Mesquita‐Ferrari R. A.; Martins V. C.; Plepis A. M.; Zanotto E. D.; Peitl O.; Ribeiro D.; van den Beucken J. J.; Renno A. C. M.;

  • 作者单位

    Department of BiosciencesFederal University of S?o Paulo (UNIFESP)Santos S?o Paulo Brazil;

    Department of BiosciencesFederal University of S?o Paulo (UNIFESP)Santos S?o Paulo Brazil;

    Department of BiosciencesFederal University of S?o Paulo (UNIFESP)Santos S?o Paulo Brazil;

    Department of BiosciencesFederal University of S?o Paulo (UNIFESP)Santos S?o Paulo Brazil;

    Department of BiosciencesFederal University of S?o Paulo (UNIFESP)Santos S?o Paulo Brazil;

    Department of Rehabilitation Sciences and Biophotonics Applied to Health SciencesNove de Julho;

    Department of Rehabilitation Sciences and Biophotonics Applied to Health SciencesNove de Julho;

    Institute of Chemistry University of S?o Paulo (USP)S?o Carlos S?o Paulo Brazil;

    Institute of Chemistry University of S?o Paulo (USP)S?o Carlos S?o Paulo Brazil;

    Vitreous Materials Laboratory (LaMaV) Department of Materials EngineeringFederal University of S?o;

    Vitreous Materials Laboratory (LaMaV) Department of Materials EngineeringFederal University of S?o;

    Department of BiosciencesFederal University of S?o Paulo (UNIFESP)Santos S?o Paulo Brazil;

    Department of BiomaterialsRadboudumcNijmegen The Netherlands;

    Department of BiosciencesFederal University of S?o Paulo (UNIFESP)Santos S?o Paulo Brazil;

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  • 正文语种 eng
  • 中图分类 医用一般科学;
  • 关键词

    biomaterials availability; bioactive glass; polymer; cytotoxicity; bone;

    机译：生物材料可用性;生物活性玻璃;聚合物;细胞毒性;骨头;

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