...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Amoxicillin‐loaded electrospun nanocomposite membranes for dental applications
【24h】

Amoxicillin‐loaded electrospun nanocomposite membranes for dental applications

机译：加载Amoxicillin的电纺纳米复合材料牙科应用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Electrospun nanocomposite matrices based on poly(ε‐caprolactone) (PCL), nano‐hydroxyapatite (nHAp) and amoxicillin (AMX) were designed and investigated for dental applications. nHAp provides good biocompatibility, bioactivity, osteoconductivity, and osteoinductivity properties, and AMX, as antibiotic model, controls and/or reduces bacterial contamination of periodontal defects while enhancing tissue regeneration. A series of polymeric nanocomposites was obtained by varying both the antibiotic and nHAp contents. Fibrous membranes of different compositions were obtained by electrospinning technique, and morphological, thermal, mechanical and surface properties were characterized. The incorporation of AMX seemed to alter the nHAp distribution within the microfibrous matrix. The interaction between AMX and nHAp affected the mechanical performance and modulated the antibiotic release behavior. AMX release profiles presented a burst release that depended on nHAp content, followed by a slow release stage where the drug content (85–100%) was released in 3 weeks. The antimicrobial activity of the AMX‐loaded membranes was tested with four bacterial strains depended on both the drug and nHAp contents. Extensive mineralization in simulated body fluid (SBF) was evidenced by SEM/EDX analysis after 21 days. The studied electrospun nanocomposite amoxicillin‐loaded membranes could be a promising fibrous‐based antibiotic carrier system for dental and tissue engineering applications. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 966–976, 2017.
机译：摘要为牙科应用设计并研究了基于聚（ε-己内酯）（PCL），纳米 - 羟基磷灰石（NHAP）和阿莫西林（AMX）的电纺纳米复合矩阵。 NHAP提供良好的生物相容性，生物活性，骨导电性和骨诱导性能，以及AMX，作为抗生素模型，对照和/或降低牙周缺陷的细菌污染，同时增强组织再生。通过改变抗生素和NHAP含量来获得一系列聚合物纳米复合材料。通过静电纺丝技术获得不同组合物的纤维膜，并表征了形态学，热，机械和表面性质。 AMX的掺入似乎改变了微纤维基质内的NHAP分布。 AMX和NHAP之间的相互作用影响了机械性能并调节了抗生素释放行为。 AMX释放型材呈现了突发释放，依赖于NHAP含量，其次是慢释放阶段，其中药物含量（85-100％）在3周内释放。用四种细菌菌株测试AMX负载膜的抗微生物活性依赖于药物和NHAP含量。模拟体液（SBF）的广泛矿化通过21天后SEM / EDX分析证明了SEM / EDX分析。研究的电纺纳米复合氨毒素负载膜可能是牙科和组织工程应用的有前途的纤维类抗生素载体系统。还2016 Wiley期刊，INC.J生物保解率A件B：苹果生物检索物，105B：966-976，2017。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号