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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Characteristics of synovial fluid required for optimization of lubrication fluid for biotribological experiments
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Characteristics of synovial fluid required for optimization of lubrication fluid for biotribological experiments

机译：优化生物实验润滑液所需的滑膜特性

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Abstract Wear testing of total joint replacement (TJR) is mandatory in preclinical testing before implantation of TJR into the human body. Testing is governed by current international standards that recommend bovine serum (BS) as a lubricating fluid to replace synovial fluid (SF). Recently, the use of BS has been criticized because of differences in content, fluid characteristics, and nonhuman origin. As a result, a more realistic lubricant mimicking SF is needed. To define SF composition, we analyzed SF obtained during revisions of total hip and knee arthroplasties and compared it with SF obtained during primary arthroplasties and from patients without TJR. Samples were acquired from 152 patients. We found that the median total protein concentration for all SF was 36.8 mg/mL, which is significantly higher than concentrations currently recommended by the ISO standards. The γ‐globulin concentration was significantly higher and the phospholipid concentration significantly lower in patients with revision of TJR compared with patients without TJR. No significant difference was found in hyaluronic acid concentration and viscosity among the groups. Our results support the need to improve the definition of a more clinically relevant wear testing lubricant in the ISO standards. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1422–1431, 2017.
机译：摘要总关节置换（TJR）的磨损试验在临床前测试前是在植入TJR进入人体之前的临床前测试。测试受当前国际标准的管辖，推荐牛血清（BS）作为润滑液以替代滑膜（SF）。最近，由于内容，流体特性和非人类来源的差异，使用BS的使用受到批评。结果，需要一种更现实的润滑剂模仿SF。为了定义SF组合物，我们分析了在总髋关节和膝关节育化术期间获得的SF，并将其与原发性关节塑化术期间获得的SF与没有TJR的患者进行比较。样品从152名患者中获得。我们发现，所有SF的中位数总蛋白质浓度为36.8mg / ml，显着高于ISO标准目前推荐的浓度。与没有TJR的患者，γ-球蛋白浓度明显升高，磷脂浓度明显降低TJR的患者。在透明质酸浓度和基团中的粘度下没有发现显着差异。我们的结果支持在ISO标准中提高更具临床相关磨损测试润滑剂的定义。还2016 Wiley期刊，Inc。J生物保解率B部分B：苹果生物炉，105B：1422-1431,2017。

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