...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Surgical sealants with tunable swelling, burst pressures, and biodegradation rates
【24h】

Surgical sealants with tunable swelling, burst pressures, and biodegradation rates

机译：可调谐膨胀，爆发压力和生物降解率的外科密封剂

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract We developed two types of polyethylene glycol (PEG)‐based surgical sealants, which we have termed the PER and PRO series. In one, the PRO series, an 8‐arm PEG containing activated carbonyl end‐groups was reacted with a 4‐armed amino‐PEG. In the second, the PER series, a 4‐arm PEG containing bi‐functional end groups with four azides and four activated esters was reacted by strain‐promoted alkyne‐azide cycloaddition with a 4‐arm cyclooctyne‐PEG to give a near‐ideal Tetra‐PEG hydrogel. The sealants showed predictably tunable strength, swelling, adhesion, and gelation properties. The gels were compared to commercially available PEG‐based sealants and exhibit physical properties equivalent to or better than the standards. Variants of each gel‐format were prepared that contained a β‐eliminative cleavable linker in the crosslinks to control degradation rate. Linkers of this type self‐cleave with half‐lives spanning from hours to years, and offer the unique ability to precisely tune the degradation to match the healing process. In addition, these linkers could serve as cleavable tethers for controlled drug release. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1602–1611, 2017.
机译：摘要我们开发了两种类型的聚乙二醇（PEG）基础的手术密封剂，我们称为PER和PRO系列。在一个Pro系列中，含有8臂PEG的活性羰基末端基团与4臂氨基-PEG反应。在第二种中，每系列，含有四个叠氮化物和四个活化酯的双官能端基团的4臂PEG通过应变促进的炔氧化物环加成与4臂环辛氏菌钉，得到近乎理想的Tetra-peg水凝胶。密封剂显示出可预见的可调谐强度，膨胀，粘附和凝胶化性能。将凝胶与市售的基于PEG的密封剂进行比较，并且表现出与标准相当于或更好的物理性质。制备每种凝胶形式的变体，其含有交联中的β-消除可切割的接头以控制降解速率。这种类型的自我切割的联系方式，从几小时跨越多年来的半衰期，并提供精确调整劣化以匹配愈合过程的独特能力。此外，这些接头可以作为可裂解的测量药物释放。还2016 Wiley期刊，INC.J生物保解率A型B：苹果生物检索物，105B：1602-1611,2017。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号