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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Augmenting the bioactivity of polyetheretherketone using a novel accelerated neutral atom beam technique
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Augmenting the bioactivity of polyetheretherketone using a novel accelerated neutral atom beam technique

机译：使用新型加速中性原子束技术增强聚醚醚酮的生物活性

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Abstract Summary Polyetheretherketone (PEEK) is an alternative to metallic implants in orthopedic applications; however, PEEK is bioinert and does not osteointegrate. In this study, an accelerated neutral atom beam technique (ANAB) was employed to improve the bioactivity of PEEK. The aim was to investigate the growth of human mesenchymal stem cells (hMSCs), human osteoblasts (hOB), and skin fibroblasts (BR3G) on PEEK and ANAB PEEK. Methods The surface roughness and contact angle of PEEK and ANAB PEEK was measured. Cell metabolic activity, proliferation and alkaline phosphatase (ALP) was measured and cell attachment was determined by quantifying adhesion plaques with cells. Results ANAB treatment increased the surface hydrophilicity [91.74?±?4.80° (PEEK) vs. 74.82?±?2.70° (ANAB PEEK), p ??0.001] but did not alter the surface roughness. Metabolic activity and proliferation for all cell types significantly increased on ANAB PEEK compared to PEEK ( p ??0.05). Significantly increased cell attachment was measured on ANAB PEEK surfaces. MSCs seeded on ANAB PEEK in the presence of osteogenic media, expressed increased levels of ALP compared to untreated PEEK ( p ??0.05) Conclusion Our results demonstrated that ANAB treatment increased the cell attachment, metabolic activity, and proliferation on PEEK. ANAB treatment may improve the osteointegration of PEEK implants. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1438–1446, 2017.
机译：摘要发明内容聚醚醚酮（PEEK）是矫形应用中金属植入物的替代品;但是，PEEK是生物素线，不会骨骨。在该研究中，采用加速中性原子束技术（ANAB）来改善PEEK的生物活性。目的是探讨人间充质干细胞（HMSCs），人成骨细胞（滚刀）和皮肤成纤维细胞（BR3G）的生长（BR3G）。方法测量PEEK和ANAB PEEK的表面粗糙度和接触角。测定细胞代谢活性，增殖和碱性磷酸酶（ALP），通过用细胞定量粘附斑块测定细胞附着。结果Anab治疗增加了表面亲水性[91.74吗？与PEEK相比，ANAB PEEK的代谢活性和所有细胞类型的增殖显着增加（P？＆ 0.05）。在Anab Peek表面上测量显着增加的细胞连接。与未经处理的PEEK相比，在骨质发生介质存在下播种在ANAB窥视上，表达了ALP水平增加（p≤0.05）结论我们的结果表明，ANAB治疗增加了细胞附着，代谢活性和PEEK的增殖。 Anab治疗可以改善PEEK植入物的骨折叠。还2016 Wiley期刊，INC.J生物保解员B部分B：Appl Biomater，105B：1438-1446,2017。

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