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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Degradation behaviors and cytocompatibility of Mg/beta-tricalcium phosphate composites produced by spark plasma sintering
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Degradation behaviors and cytocompatibility of Mg/beta-tricalcium phosphate composites produced by spark plasma sintering

机译：火花等离子体烧结产生的Mg /β-磷酸钙复合材料的降解行为和细胞组合性

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摘要

Magnesium (Mg)-based materials have shown great potentials for bioresorbable implant applications. Previous studies showed that Mg with 10 and 20 vol % beta-tricalcium phosphate (beta-TCP) composites produced by spark plasma sintering, improved mechanical properties when compared with pure Mg. The objectives of this study were to evaluate the degradation behaviors of Mg/10% beta-TCP and Mg/20% beta-TCP composites in revised stimulated body fluid (rSBF), and to determine their cytocompatibility with bone marrow derived mesenchymal stem cells (BMSCs) using the direct culture method. During the 11 days of immersion in rSBF, Mg/beta-TCP composites showed different degradation behaviors at different immersion periods, that is, the initial stage (0-1 hr), the mid-term stage (1 hr to 2 days), and the long-term stage (2-11 days). The counter effects of mass loss due to microgalvanic corrosion and mass gain due to deposition of Ca-P containing layers resulted in slower Mg2+ ion release for Mg/20% beta-TCP than Mg/10% beta-TCP in the mid-term, but eventually 16% mass loss for Mg/20% beta-TCP and 10% mass loss for Mg/10% beta-TCP after 11 days of immersion. The in vitro studies with BMSCs showed the highest cell adhesion density (i.e., 68% of seeding density) on the plate surrounding the Mg/10% beta-TCP sample, that is, under the indirect contact condition of direct culture. The beta-TCP showed a positive effect on direct adhesion of BMSCs on the surface of Mg/beta-TCP composites. This study elucidated the degradation behaviors and the cytocompatibility of Mg/beta-TCP composites in vitro; and, further studies on Mg/ceramic composites are needed to determine their potential for clinical applications. (c) 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2238-2253, 2019.
机译：基于镁（Mg）的材料对生物可吸收植入物应用示出了很大的潜力。以前的研究表明，用火花等离子体烧结产生的10和20 Vol％的磷酸三钙（β-TCP）复合材料，与纯Mg相比，改善机械性能。本研究的目的是评估Mg / 10％Beta-TCP和Mg / 20％β-TCP复合材料在修正的刺激体液（RSBF）中的降解行为，并与骨髓衍生的间充质干细胞进行细胞势次化（ BMSCS）使用直接培养方法。在RSBF浸泡的11天内，Mg /β-TCP复合材料在不同的浸入期间显示出不同的降解行为，即初始阶段（0-1小时），中期阶段（1小时至2天），和长期阶段（2-11天）。由于微血糖腐蚀和由于Ca-P含量的沉积而引起的质量损失的反应作用导致Mg / 20％Beta-TCP的Mg / 20％Beta-TCP较慢的Mg2 +离子释放，但最终在浸泡11天后Mg / 20％Beta-TCP的16％质量损失和Mg / 10％β-TCP的10％质量损失。与BMSC的体外研究显示出围绕Mg / 10％Beta-TCP样品的板上的电池粘附密度（即68％的播种密度），即在直接培养的间接接触条件下。 Beta-TCP对Mg /β-TCP复合材料表面上BMSCs的直接粘附表现出积极影响。本研究阐明了体外降解行为和Mg / Beta-TCP复合材料的细胞组分;并且，需要进一步研究Mg /陶瓷复合材料以确定它们对临床应用的潜力。 （c）2019年Wiley期刊，Inc。J生物保解率A件B：苹果生物机107B：2238-2253，2019。

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