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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Akermanite reinforced PHBV scaffolds manufactured using selective laser sintering
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Akermanite reinforced PHBV scaffolds manufactured using selective laser sintering

机译：使用选择性激光烧结制造的Akermanite强化PHBV支架

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Scaffold assisted tissue engineering presents a promising approach to repair diseased and fractured bone. For successful bone repair, scaffolds need to be made of biomaterials that degrade with time and promote osteogenesis. Compared to the commonly used ss-tricalcium phosphate scaffolds, Akermanite (AKM) scaffolds were found to degrade faster and promote more osteogenesis. The objective of this study is to synthesize AKM micro and nanoparticle reinforced poly(3-hydroxybutyrate-co-3-hydroxyvalerate; PHBV) composite scaffolds using selective laser sintering (SLS). The synthesized composite scaffolds had an interconnected porous microstructure (61-64% relative porosity), large specific surface areas (31.1-64.2 mm(-1)) and pore sizes ranging from 303 to 366 and 279 to 357 mu m in the normal and lateral direction, respectively, which are suitable for bone tissue repair. The observed hydrophilic nature of the scaffolds and the swift water uptake was due to the introduction of numerous carboxylic acid groups on the scaffold surface after SLS, circumventing the need for postprocessing. For the composite scaffolds, large amounts of AKM particles were exposed on the skeleton surface, which is a requirement for cell attachment. In addition, the particles embedded inside the skeleton helped to significantly reinforce the scaffold structure. The compressive strength and modulus of the composite scaffolds were up to 7.4 and 103 MPa, respectively, which are 149 and 197% of that of the pure PHBV scaffolds. (c) 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2596-2610, 2019.
机译：脚手架辅助组织工程呈现了一种有希望的方法来修复患病和骨折骨骼。对于成功的骨骼修复，支架需要由患有时间降解并促进成骨的生物材料制成。与常用的SS-磷酸钙支架相比，发现αkermanite（Akm）支架较快降低并促进更高的骨质发生。本研究的目的是使用选择性激光烧结（SLS）合成Akm微型和纳米颗粒增强聚（3-羟基巴丁酸酯-CO-3-羟基戊羟戊烯; PHBV）复合支架。合成的复合支架具有相互连接的多孔微观结构（61-64％的相对孔隙率），大的比表面积（31.1-64.2mm（-1））和孔径在正常和孔径范围为303至366和279至357μm。分别适用于骨组织修复的横向。观察到的支架和Swift水摄取的亲水性质是由于在SLS之后引入了支架表面上的许多羧酸基团，避免了对后处理的需求。对于复合支架，大量的Akm颗粒暴露在骨架表面上，这是对细胞附着的要求。此外，嵌入骨架内部的颗粒有助于显着加强支架结构。复合支架的抗压强度和模量分别为7.4和103MPa，其为纯PHBV支架的149和197％。 （c）2019年Wiley期刊，Inc。J生物保解员B：Appl Biomater 107B：2596-2610,2019。

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