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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Porous and nonporous silk fibroin (SF) membranes wrapping for Achilles tendon (AT) repair: Which one is a better choice?
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Porous and nonporous silk fibroin (SF) membranes wrapping for Achilles tendon (AT) repair: Which one is a better choice?

机译：多孔和无孔丝素蛋白（SF）膜包裹腱腱（AT）修复：哪一个是更好的选择？

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Abstract Two types of silk fibroin (SF) membranes were developed for tendon repair: porous and nonporous SF membranes. The objective of this study was to compare the efficiency of these two films according to the ability of tendon regeneration using a rat Achilles tendon (AT) rupture suture wrapping model. The in vitro tests were conducted, and theSF membranes were proved to be with ultimate‐biodegradability, good‐biocompatibility and without toxicity. In vivo , 12 Sprague Dawley rats were used to create a rat AT rupture suture model wrapped by SF membranes. They were randomly divided into six groups. The results revealed that the nonporous SF membrane wrapping group was shown to reduce the inflammatory effect and induce the proliferation of fibroblast‐like cells at one week and four weeks post‐operatively. After four weeks, the nonporous SF membrane wrapping group exhibited more organized collagen structures and had increased expression of tendon repair proteins. Hence, our nonporous SF membrane improved the efficacy of tendon regeneration by decreasing inflammatory cells, growing fibroblast‐like cells, and promoting extracellular matrix production. Nonporous SF membrane can, therefore, be regarded as a better functional membrane for tendon repair. ? 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: 00B: 000–000, 2018. ? 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 733–740, 2019.
机译：摘要为肌腱修复开发了两种丝素蛋白（SF）膜：多孔和无孔SF膜。本研究的目的是根据使用大鼠Achilles肌腱（AT）破裂缝合包裹模型的肌腱再生能力来比较这两种膜的效率。进行了体外测试，并证明了该膜具有最终 - 生物相容性，良好的生物相容性和无毒性。在体内，12只Sprague Dawley大鼠用于在SF膜包裹的破裂缝合模型中产生大鼠。他们随机分为六组。结果表明，无孔的SF膜包装组被证明可减少炎症作用，并在可操作地诱导成纤维细胞样细胞的增殖。四周后，无孔的SF膜包裹组呈现更多有组织的胶原蛋白结构，并增加了肌腱修复蛋白的表达。因此，我们的无孔的SF膜通过减少炎性细胞，生长成纤维细胞样细胞和促进细胞外基质产生来改善肌腱再生的功效。因此，无孔SF膜可以被视为肌腱修复的更好的功能膜。还2018 Wiley期刊，Inc.J生物保解员A部分B：00B：000-000，2018.？ 2018 Wiley期刊，Inc。J生物保解率B：苹果生物粉末107B：733-740,2019。

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