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首页> 外文期刊>Journal of biomedical nanotechnology >Facile Optimization and Evaluation of PEG–PCL Block Copolymeric Nanoparticles for Anticancer Drug Delivery Using Copolymer Hybrids and Histoculture Drug Response Assays
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Facile Optimization and Evaluation of PEG–PCL Block Copolymeric Nanoparticles for Anticancer Drug Delivery Using Copolymer Hybrids and Histoculture Drug Response Assays

机译：共聚物杂交种和组织培养药物反应测定的抗癌药物递送PEG-PCL嵌段共聚物纳米粒子的体积优化和评价

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摘要

The traditional method of optimizing poly(ethyleneglycol)–polycaprolactone (PEG–PCL) copolymers for drug delivery requires high reaction temperatures, long reaction times, and various organic reagents. Furthermore, the in vivo evaluations of the antitumor effectsof these drug delivery systems are time consuming, with animal sacrifice, and negative environmental effects. In this paper, nanoparticles (NPs) prepared from PEG–PCL/PCL hybrids were obtained by mixing PEG–PCL and PCL copolymer in different proportions and used to deliver cisplatin,a widely used anticancer drug. Histoculture drug response assay (HDRA), a predictive method typically used to evaluate chemosensitivity, was applied to evaluate the in vivo antitumor potencies of the NPs. The PEG–PCL and PCL proportions of the PEG–PCL/PCL hybrid were foundto affect the NP diameter, drug loading content, encapsulation efficiency, stability, in vitro release properties, in vitro cytotoxicity, and antitumor effect in HDRA. The optimal NPs exhibited a satisfactory antitumor effect along with comparatively low side effects during an in vivo study in a murine model. The results reveal that PEG–PCL/PCL hybrids and HDRA can be used to conveniently and easily optimize and evaluate NPs prepared from block copolymers.
机译：优化聚（乙二醇） - 聚己内酯（PEG-PCL）共聚物用于药物递送的传统方法需要高反应温度，长反应时间和各种有机试剂。此外，这些药物递送系统的抗肿瘤作用的体内评价是耗时的，具有动物牺牲和负面的环境影响。在本文中，通过将PEG-PCL和PCL共聚物混合在不同比例中并用于递送顺铂，广泛使用的抗癌药物来获得纳米颗粒（NPS）。组织培养药物反应测定法（HDRA），一种通常用于评估化学敏感性的预测方法，用于评估NPS的体内抗肿瘤效率。发现PEG-PCL / PCL杂交物的PEG-PCL和PCL比例，影响HDRA中的NP直径，药物载量，包封效率，稳定性，体外释放性能，体外细胞毒性和抗肿瘤作用。最佳NPS在鼠模型中的体内研究期间表现出令人满意的抗肿瘤效果以及相对低的副作用。结果表明，PEG-PCL / PCL杂交物和HDRA可用于方便且容易地优化和评估由嵌段共聚物制备的NP。

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