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首页> 外文期刊>Journal of bone and mineral metabolism >Differences in bone mineral density, bone mineral content, and bone areal size in fracturing and non-fracturing women, and their interrelationships at the spine and hip.
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Differences in bone mineral density, bone mineral content, and bone areal size in fracturing and non-fracturing women, and their interrelationships at the spine and hip.

机译：压裂和非压裂妇女骨密度，骨矿物质含量和骨骼大小的差异，以及它们在脊柱和臀部的相互关系。

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Osteoporotic fractures are a major public health problem, particularly in women. Bone mineral density (BMD), bone mineral content (BMC), and bone size have been regarded as important determinants of osteoporotic fractures. In 1449 women over age 30 years, we studied the detailed relationship, at the spine and hip, between BMD, BMC, and bone areal size (all measured by dual-energy X-ray absorptiometry) and compared their relative magnitudes in fracturing and non-fracturing individuals. We find that, (1) BMD and BMC are significantly higher at the spine and hip in non-fracturing women. Bone areal size is significantly larger at the spine in non-fracturing women; however, the significance disappears when adjustment is made for the significant difference of height (stature) between fracturing and non-fracturing women. In contrast to the spine, bone areal size is always significantly largerin fracturing women at the hip. (2) The relationship among BMD, BMC, and bone areal size is different at the spine and hip. Specifically, at the spine, BMD increases with bone areal size linearly. At the hip, BMD has a quadratic relationship with bone areal size, so that BMD increases at lower bone areal sizes, then (after an intermediate zone of values) decreases with increasing bone areal size. However, BMD adjusted for BMC always decreases with increasing bone areal size, as expected by the definition of BMD. With no adjustment for BMC, the increase in BMD with bone areal size is due to a more rapid increase of BMC than increasing bone areal size, thus explaining the observations of association of both larger BMD and larger bone areal size with stronger bone. (3) At the spine, 86.2% of BMD variation is attributable to BMC and 12.6% to bone areal size. At the hip, 98.0% of BMD variation is due to BMC and 1.1% due to bone areal size. The current study may be important in understanding the relationship among BMD, BMC, and bone size as risk determinants of osteoporotic fractures.
机译：骨质疏松骨折是一个主要的公共卫生问题，特别是女性。骨矿物密度（BMD），骨矿物质含量（BMC）和骨骼大小被认为是骨质疏松骨折的重要决定因素。在30岁以上的1449岁以上，我们在BMD，BMC和骨骼面积之间进行了详细的关系，在BMD，BMC和骨骼面积之间（通过双能X射线吸收测量测量），并将其相对幅度与压裂和非 - 违反个体。我们发现，（1）BMD和BMC在非压裂妇女的脊柱和臀部显着高。在非压裂妇女的脊柱上骨骼大小明显较大;然而，当压裂和非压裂妇女之间的高度（地位）的显着差异进行调整时，显着性消失。与脊柱相比，骨骼大小总是在臀部的裂缝妇女均显着大幅增加。 （2）BMD，BMC和骨骼大小之间的关系在脊柱和臀部不同。具体地，在脊柱上，BMD线性地骨骼尺寸增加。在臀部，BMD具有与骨骼面积的二次关系，因此BMD在较低的骨骼面积上增加，然后（值的中间区域）随着骨骼的增加而降低。然而，根据BMD的定义，BMC调整的BMC调整的BMD总是随着骨骼面积的增加而降低。没有对BMC进行调整，BMD的增加具有骨骼的尺寸是由于BMC的快速增加而不是增加骨骼面积，因此解释了较大的BMD和较大的骨骼大小与较强的骨骼的关联观察。 （3）在脊柱上，86.2％的BMD变异可归因于BMC和12.6％的骨骼面积。在臀部，98.0％的BMD变异是由于BMC和1.1％由于骨骼大小。目前的研究对于了解BMD，BMC和骨骼大小之间的关系是作为骨质疏松骨折的风险决定因素的关系。

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