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首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Sexual Dimorphism in Cortical and Trabecular Bone Microstructure Appears During Puberty in Chinese Children
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Sexual Dimorphism in Cortical and Trabecular Bone Microstructure Appears During Puberty in Chinese Children

机译：中国儿童青春期出现皮质和小梁骨微观结构中的性二态

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ABSTRACT Distal forearm fractures during growth are more common in males than females. Because metaphyseal cortical bone is formed by coalescence of trabeculae emerging from the periphery of the growth plate, we hypothesized that the later onset of puberty in males produces a longer delay in trabecular bone formation and coalescence, which leaves a transient phase of high cortical porosity, low matrix mineral density, and high trabecular density relative to females. We quantified the nondominant distal radial microstructure using high‐resolution peripheral quantitative computed tomography in 214 healthy Chinese boys and 219 Chinese girls aged between 7 and 17 years living in Hong Kong. Measurements of 110 slices (9.02?mm) were acquired 5?mm proximal to the growth plate of the nondominant distal radius. Porosity was measured using StrAx1.0 (Straxcorp, Melbourne, VIC, Australia) and trabecular plate and rod structure were measured using individual trabecula segmentation (ITS). Mechanical properties were estimated using finite element analysis (FEA). Results were adjusted for age, total bone cross‐sectional area (CSA), dietary calcium intake, and physical activity. In boys, total bone CSA was 17.2% to 22.9% larger throughout puberty, cortical/total bone CSA was 5.1% smaller in Tanner stage 2 only, cortical porosity was 9.4% to 17.5% higher, and matrix mineral density was 1.0% to 2.5% lower in Tanner stage 2 to 5, than girls. Boys had higher trabecular rod BV/TV in Tanner stage 3 and 4, but higher trabecular plate BV/TV and plate to rod ratio in Tanner stage 5, than girls. Boys had 17.0% lower apparent modulus than girls in Tanner stage 2. A transient phase of higher porosity due to dissociation between bone mineral accrual and linear growth may contribute to higher distal radial bone fragility in Chinese boys compared to girls. ? 2018 American Society for Bone and Mineral Research.
机译：摘要在生长期间的远端前臂骨折比女性更常见。因为通过从生长板的周边出现的小梁的组合形成的半胱氨酸皮质骨形成，所以我们假设雄性雌性的后期发作产生较长的骨形成和聚结的延迟，这留下了高皮质孔隙率的瞬态阶段，低矩阵矿物密度，以及相对于女性的高2英制密度。我们量化了在香港214名健康中国男孩的高分辨率外周定量计算断层扫描中使用高分辨率外周定量计算断层扫描的无径向微观结构。将110切片（9.02Ωmm）的测量值近侧到Nondominant远端半径的生长板上获得5·mm。使用STRAX1.0（结构，墨尔本，VIC，澳大利亚）测量孔隙率，使用单个小梁分段（其）测量小梁板和杆状结构。使用有限元分析（FEA）估计机械性能。结果调整了年龄，总骨横截面积（CSA），膳食钙摄入和身体活动。在男孩中，在Puerberty中总骨CSA为17.2％至22.9％，皮质/总骨CSA在坦纳阶段2中较小5.1％，皮质孔隙率为9.4％至17.5％，而基质矿物质密度为1.0％至2.5 Tanner阶段2至5的百分比比女孩更低。男孩在Tanner Stage 3和4中有更高的小马刺杆BV /电视，但在Tanner第5阶段，较高的小梁板BV /电视和板块与杆比的杆比。男孩的表现模量低于Tanner Stage 2的女孩。由于骨矿物群或线性生长之间的解离，较高孔隙率的瞬态阶段可能导致中国男孩的远端径向骨脆弱性。还2018年美国骨骼和矿物学研究。

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