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首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women
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Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women

机译：绝经后妇女无意减肥后骨折风险增加：妇女骨质疏松症的全球纵向研究

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Increased fracture risk has been associated with weight loss in postmenopausal women, but the time course over which this occurs has not been established. The aim of this study was to examine the effects of unintentional weight loss of >= 10 lb (4.5 kg) in postmenopausal women on fracture risk at multiple sites up to 5 years after weight loss. Using data from the Global Longitudinal Study of Osteoporosis in Women (GLOW), we analyzed the relationships between self-reported unintentional weight loss of >= 10 lb at baseline, year 2, or year 3 and incident clinical fracture in the years after weight loss. Complete data were available in 40,179 women (mean age +/- SD 68 +/- 8.3 years). Five-year cumulative fracture rate was estimated using the Kaplan-Meier method, and adjusted hazard ratios for weight loss as a time-varying covariate were calculated from Cox multiple regression models. Unintentional weight loss at baseline was associated with a significantly increased risk of fracture of the clavicle, wrist, spine, rib, hip, and pelvis for up to 5 years after weight loss. Adjusted hazard ratios showed a significant association between unintentional weight loss and fracture of the hip, spine, and clavicle within 1 year of weight loss, and these associations were still present at 5 years. These findings demonstrate increased fracture risk at several sites after unintentional weight loss in postmenopausal women. This increase is found as early as 1 year after weight loss, emphasizing the need for prompt fracture risk assessment and appropriate management to reduce fracture risk in this population. (C) 2016 American Society for Bone and Mineral Research.
机译：骨折风险的增加与绝经后妇女的体重减轻有关，但尚未建立这种情况的时间课程。本研究的目的是检查绝经后妇女在绝经后妇女在减肥后5年后的骨折风险上的绝经后妇女在绝经后妇女对骨折风险的影响。使用来自妇女骨质疏松症的全局纵向研究的数据（发光），我们分析了在减肥后的基线，2年级或第3年和第3年和第3年和第3年和第3年和第3年和第3年和事件临床骨折之间的自我报告的无意减肥之间的关系。在40,179名女性中提供完整数据（平均年龄+/- SD 68 +/- 8.3岁）。使用Kaplan-Meier方法估计了五年的累积裂缝率，并且根据Cox多元回归模型计算了作为时变协变量的重量损失的调整后危险比。基线的无意减肥与锁骨，手腕，脊柱，肋骨，肋骨，骨质骨折的风险显着增加，减肥后长达5年的骨盆。调整后的危险比率显示在减肥1年内髋关节，脊柱和锁骨的无意减肥和裂缝之间的显着关联，并且这些关联仍存在于5年。这些研究结果表明在绝经后妇女无意减肥后几个地点的骨折风险增加。在减肥后的1年内发现这种增加，强调需要提示骨折风险评估和适当的管理，以减少该人群的骨折风险。 （c）2016年美国骨骼和矿物学学会。

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