Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins

Dyson H. Jane; Wright Peter E.

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Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins

机译：透视：NMR在本质无序蛋白发现和表征中的基本作用

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摘要

The 2019 ISMAR Prize recognized NMR studies of disordered proteins. Here we provide a highly personal perspective on the discovery of intrinsically disordered proteins and the development and application of NMR methods to characterize their conformational ensembles, dynamics, and interactions.

机译：2019年ISMAR奖项认可的疾病蛋白质核苷酸研究。在这里，我们对本质无序蛋白质的发现和NMR方法的开发和应用提供了高度个人的视角，以表征其构象整合，动力学和相互作用。

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《Journal of Biomolecular NMR》 |2019年第12期|共9页
作者
Dyson H. Jane; Wright Peter E.;
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作者单位

Scripps Res Inst Dept Integrat Struct &

Computat Biol 10550 North Torrey Pines Rd La Jolla CA 92037 USA;

Scripps Res Inst Dept Integrat Struct &

Computat Biol 10550 North Torrey Pines Rd La Jolla CA 92037 USA;

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原文格式 PDF
正文语种 eng
中图分类分子生物学;
关键词
Intrinsically disordered proteins; Immunogenic peptides; Protein folding; Relaxation dispersion;

机译：本质无序的蛋白质;免疫原肽;蛋白质折叠;松弛分散;

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专利

1. Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins [J] . Dyson H. Jane, Wright Peter E. Journal of Biomolecular NMR . 2019,第12期

机译：透视：NMR在本质无序蛋白发现和表征中的基本作用
2. NMR characterization of solvent accessibility and transient structure in intrinsically disordered proteins [J] . Hartlmueller Christoph, Spreitzer Emil, Gobl Christoph, Journal of Biomolecular NMR . 2019,第6a7期

机译：本质无序蛋白质中溶剂可接近性和瞬态结构的NMR表征
3. NMR Characterization of Long‐Range Contacts in Intrinsically Disordered Proteins from Paramagnetic Relaxation Enhancement in ^{1313 C Direct‐Detection Experiments} [J] . Mateos Borja, Konrat Robert, Pierattelli Roberta, Chembiochem: A European journal of chemical biology . 2019,第3期

机译：NMR在本质上无序蛋白质中的远程触点，来自顺磁性松弛增强 13 13 c直接检测实验
4. Protein Intrinsic Disorder, Cell Signaling, Drug Discovery, and Alternative Splicing [C] . A. Keith Dunker International Conference on Bioinformatics and Computational Biology . 2007

机译：蛋白质内在病症，细胞信号，药物发现和替代剪接
5. The roles of lithium(+), magnesium(2+), and sodium ions in bipolar disorder and essential hypertension: A multinuclear NMR and fluorescence study [D] . Williams, Nicole Marie. 2002

机译：锂（+），镁（2+）和钠离子在躁郁症和原发性高血压中的作用：多核NMR和荧光研究
6. Structural Characterization of Intrinsically Disordered Proteins by NMR Spectroscopy [O] . Simone Kosol, Sara Contreras-Martos, Cesyen Cedeño, 2013

机译：内在无序蛋白的核磁共振谱的结构表征
7. Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins [O] . H. Jane Dyson, Peter E. Wright 2019

机译：透视：NMR在本质上无序蛋白发现和表征中的基本作用

Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins

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