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首页> 外文期刊>Journal of addiction medicine >Medication Adherence Monitoring Using Smartphone Video Dosing in an Open-label Pilot Study of Monthly Naltrexone Plus Once-daily Bupropion for Methamphetamine Use Disorder: Feasibility and Acceptability
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Medication Adherence Monitoring Using Smartphone Video Dosing in an Open-label Pilot Study of Monthly Naltrexone Plus Once-daily Bupropion for Methamphetamine Use Disorder: Feasibility and Acceptability

机译：使用智能手机视频给药在每月Naltrexone的开放标签试验研究中使用智能手机视频给药的申请监测加上每日每日一次Bupropion用于甲基苯丙胺使用障碍：可行性和可接受性

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Objectives: This article describes how smartphones were used to monitor and encourage medication adherence in a pilot study evaluating the potential efficacy of a combination pharmacotherapy for methamphetamine use disorder. We examine the feasibility, utility, and acceptability of using smartphones to capture dosing videos from the perspectives of participants and staff. Methods: The study was an 8-week, open-label evaluation of extended-release injectable naltrexone combined with once-daily oral extended-release bupropion (BRP, Welbutrin XL, 450 mg/day). Participants attended visits twice-weekly for observed BRP dosing, assessments, and medical management. BRP was dispensed once weekly for dosing on nonclinic days. Medication adherence was assessed objectively (by observation in the clinic and smartphone videos for dosing at home) and subjectively (self-reports of dosing). Surveys assessing the smartphone component were completed by participants and study staff. Results: Participants (N = 49) reported taking 93.6% of the dispensed BRP doses while 86.6% of dispensed doses were confirmed via dosing video and in-person observations. Most participants who completed the survey agreed that the smartphone was easy to use (92.6%) and that taking the dosing videos helped to remember to take the study medication (80.5%). Staff agreed that the smartphone helped collect accurate dosing data for most (77.5%) participants. Conclusions: The use of smartphones for video-based oral medication dosing in this study provided a feasible and acceptable mechanism to encourage, monitor, and confirm medication adherence. Video-confirmed dosing adherence provides an objective numerical indicator of the lowest medication adherence rate participants achieve, allowing investigators to more confidently interpret results.
机译：目的：本文介绍了智能手机如何用于监测和促进试点研究中的药物遵守，评估组合药物治疗对甲基苯丙胺使用障碍的潜在疗效。从参与者和工作人员的角度来看，我们检查使用智能手机捕获给药视频的可行性，效用和可接受性。方法：该研究是8周，扩展释放可注射纳曲酮的开放式标签评估，结合一次每日口服延长释放的Bupropion（BRP，Welbutrin XL，450毫克/天）。参与者参加两次每周一次访问，因为观察到的BRP给药，评估和医疗管理。每周一次分配一次，以便在非临碳日内给药。客观地评估药物遵守（通过在家里给药的诊所和智能手机视频的观察）和主观（给药的自我报告）。评估智能手机组件的调查由参与者和学习人员完成。结果：参与者（N = 49）报告称93.6％的分配BRP剂量，而86.6％的分配剂量通过给药视频和亲自观察来确认。大多数完成调查的参与者都同意智能手机易于使用（92.6％），并将给药视频有助于记住参加研究药物（80.5％）。工作人员同意，智能手机有助于为大多数（77.5％）参与者收集准确的给药数据。结论：在本研究中使用智能手机进行视频的口腔用药剂量，提供了一种可行和可接受的机制，可促进，监测和确认药物依从性。视频确认的给药粘附提供了最低药物依从性参与者的客观数值指标，使调查人员更加自信地解释结果。

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