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首页> 外文期刊>Journal of bronchology & interventional pulmonology >Incidence, Etiology, and Clinicopathologic Features of Endobronchial Benign Lesions - A 10-Year Consecutive Retrospective Study
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Incidence, Etiology, and Clinicopathologic Features of Endobronchial Benign Lesions - A 10-Year Consecutive Retrospective Study

机译：内核良性病变的发病，病因和临床病理特征 - 连续10年的回顾性研究

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Background: Airways can be affected by non-neoplastic lesions leading to critical stenosis of the lumen. Incidence, etiology, and clinical significance of endobronchial benign lesions are not systematically characterized. This study aimed to assess the epidemiology of nonmalignant processes involving the bronchial tree on clinical, pathologic, endoscopic, and radiologic grounds. Methods: We retrospectively analyzed bronchoscopy procedures over 10 years at the Bronchoscopy Unit of Modena University Hospital. All the endoscopically growing benign lesions with histologic confirmation were considered. For each lesion, we evaluated demographics, clinical features and outcome, the endoscopic aspect and radiologic characteristics by means of computed tomography as assessed by 2 experienced radiologists blinded with regard to the diagnosis. Results: Over the study period, we analyzed 10,431 bronchoscopies and identified 2075 cases of tracheo-bronchial alterations. Among these, 11.2% had a benign etiology with an average annual incidence of 23 new cases/year and a general incidence of 2.2%. Anthrachosis was the most prevalent bronchial lesion. In total, 22% of benign lesions presented airway stenosis >50% and required bronchoscopic treatment. Bronchial stenosis was most frequently observed in tuberculosis (P = 0.031) and aspergillosis (P = 0.020) when compared with sarcoidosis. Immunosuppressive status was significantly associated with endobronchial aspergillosis (P = 0.0001) and the 1-year survival from diagnosis resulted significantly lower irrespectively to the immune system condition. Conclusions: A consistent proportion of endobronchial benign lesions are reported. One fifth of these are associated with critical stenosis of the airway lumen, requiring rigid bronchoscopy. Among these, aspergillosis is characterized by the poorest prognosis, regardless of host immunity status.
机译：背景：气道可受到非肿瘤病变的影响，导致腔的临界狭窄。没有系统地表征了内核良性病变的发病，病因和临床意义。本研究旨在评估涉及支气管树的非开始过程的流行病学，病理学，内窥镜和放射学。方法：我们回顾性地分析了莫德纳大学医院支气管镜尺寸超过10年的支气管镜检查。考虑所有内窥镜生长良性病变，具有组织学确认。对于每个病变，我们通过在诊断方面蒙蔽的2个经验丰富的放射科医生评估的计算断层扫描来评估人口统计学，临床特征和结果，内窥镜方面和放射学特征。结果：在研究期间，我们分析了10,431间支气管镜，并确定了2075例Tracheo-Hronchial改变。其中，11.2％具有良性病因，平均年度发病率为23例新案件/年度，一般发病率为2.2％。鎓化是最普遍的支气管病变。总共22％的良性病变呈现气道狭窄> 50％并需要支气管镜检查。与结节病相比，结核病（P = 0.031）和曲柄症（P = 0.020）中最常观察到支气管狭窄。免疫抑制状态与内核曲线症有显着相关（P = 0.0001），并且从诊断中的1年生存导致免疫系统状况显着降低。结论：报道了一致的内核良性病变比例。其中五分之一与气道内腔的临界狭窄有关，需要刚性支气管镜检查。其中，无论宿主免疫状态如何，曲柄病的特征在于预后较差。

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