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首页> 外文期刊>Journal of Alzheimer's disease: JAD >Role of Macrophages in Status Epilepticus Predisposing to Alzheimer's Disease
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Role of Macrophages in Status Epilepticus Predisposing to Alzheimer's Disease

机译：巨噬细胞在地位癫痫的作用易患阿尔茨海默病

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摘要

Continuous epileptic seizures hallmark status epilepticus, leading to preferential neuronal cell loss in the hippocampus that can progress into Alzheimer's disease. Previous studies have shown that status epilepticus prompts an overproduction of nitric oxide (NO) by upregulation of NO synthase II (NOS II) to induce apoptosis of neuronal cells in the hippocampus, in a nuclear factor-kappaB (NF-kappa B) signaling dependent manner. Here, in an experimental rat model for status epilepticus, elicitation of sustained seizure activity was achieved by microinjection of kainic acid (KA) into the hippocampal CA3 subfield. We found that KA induced features of status epilepticus, which could be attenuated by blocking NF-kappa B signaling through a specific inhibitor. Interestingly, infiltration of macrophages of primarily pro-inflammatory subtype was detected in the hippocampal CA3 region immediately after KA injection. Experimental elimination of macrophages by an anti-CD115 antibody significantly attenuated the features of status epilepticus, likely through suppressing activation of NF-kappa B signaling. Together, these data suggest that macrophages play a critical role in NF-kappa B signaling-mediated status epilepticus that predisposes to Alzheimer's disease.
机译：连续癫痫癫痫发作了Hallmark状态癫痫症，导致海马的优先神经元细胞损失，可以进入阿尔茨海默病。先前的研究表明，状态癫痫症促使一氧化氮（NO）的过量生产通过不含合酶II（NOS II）诱导海马神经元细胞凋亡，在核因子-Kappab（NF-Kappa B）信号传导中方式。这里，在状态癫痫的实验性大鼠模型中，通过将持续的癫痫发作活性引发到海马CA3子场中的kinoic acid酸（Ka）来实现。我们发现KA诱导状态癫痫的特征，其可以通过通过特定抑制剂阻断NF-Kappa B信号来衰减。有趣的是，在KA注射后立即在海马CA3区域中检测到主要促炎亚型的巨噬细胞的浸润。抗CD115抗体的实验消除巨噬细胞显着减弱了状态癫痫的特征，可能是通过抑制NF-κB信号传导的激活。这些数据在一起表明巨噬细胞在NF-Kappa发证介导的状态癫痫发挥着关键作用，该状态癫痫发挥倾向于阿尔茨海默病。

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  • 作者

    Song Shasha; Chen Jingjiong; Xiao Pinpin; Duan Hao; Zhou Yajun; Wang Feng; Wang Hongmei; Zhao Yuwu; Geng Zhi;

  • 作者单位

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Neurol Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Neurol Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Neurol Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Neurol Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Neurol Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Neurol Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Neurol Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Neurol Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Neurol Shanghai Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    Alzheimer's disease; kainic acid; macrophages; NP-kappa B; status epilepticus;

    机译：阿尔茨海默病;Kainic酸;巨噬细胞;NP-Kappa B;状态癫痫病;

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