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HIV, HAART, and lipoprotein particle concentrations in the Women's Interagency HIV Study.

机译：妇女机构间HIV研究中的HIV，HAART和脂蛋白颗粒浓度。

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BACKGROUND: Changes in lipoprotein particle concentrations, especially greater small low-density lipoprotein particle (LDL-p) and lower small high-density lipoprotein particle (HDL-p) may provide information regarding cardiovascular disease (CVD) risk above and beyond that which is provided by standard lipids. We quantified the association HIV and HAART use had with LDL-p and HDL-p. METHODS: Cross-sectional study of 1077 individuals classified by HIV/HAART status (361 HIV-uninfected, 128 HIV-infected/HAART naive, 588 HIV-infected/on HAART) enrolled in the Women's Interagency HIV Study. Nuclear magnetic resonance spectroscopy estimated total and subclass lipoprotein particle concentrations. Quantile regression models were used to estimate differences in the 10th, 25th, 50th, 75th, and 90th percentiles of the distributions of lipoprotein particle concentrations between the two HIV-infected exposure groups and HIV-uninfected controls after adjustment for demographic, nonlipid metabolic factors, and standard lipids. RESULTS: Compared with HIV-uninfected women, those on HAART had greater 75th and 90th percentiles of small LDL-p; there was little difference between HIV-infected/HAART naive and HIV-uninfected women. After adjustment for triglycerides, the association of HAART with greater 75th and 90th percentiles of small LDL-p was attenuated and no longer significant. In contrast, after adjustment for triglycerides, HIV infection irrespective of HAART status remained associated with significantly lower 10th, 25th, 50th, 75th, and 90th percentiles of small HDL-p. CONCLUSION: Our findings suggest that testing for LDL-p confers little additional information beyond triglycerides levels when assessing CVD risk. Further investigation is needed to examine the role of HDL-p in the link between HIV and CVD in women.
机译：背景：脂蛋白颗粒浓度的变化，尤其是较大的低密度小脂蛋白颗粒（LDL-p）和较低的高密度小脂蛋白颗粒（HDL-p）可能提供有关心血管疾病（CVD）风险的信息由标准脂质提供。我们量化了HIV和HAART与LDL-p和HDL-p的关联。方法：这项跨性别研究纳入了妇女机构间HIV研究，该研究按HIV / HAART状况分类（共361例未感染HIV，128例未感染HIV / HAART或588例感染了HIV / HAART）。核磁共振波谱估计脂蛋白总和亚类的浓度。在调整了人口统计学，非脂质代谢因素后，使用分位数回归模型来估计两个受HIV感染的暴露人群和未经HIV感染的对照组之间脂蛋白颗粒浓度分布的第10、25、50、75和90％的差异，和标准脂质。结果：与未感染艾滋病毒的妇女相比，接受HAART治疗的妇女的小LDL-p分别高出第75和第90个百分位。未经HIV感染/ HAART的妇女与未经HIV感染的妇女之间几乎没有差异。调整甘油三酸酯后，HAART与较小的LDL-p的第75和90％百分数的关联减弱，不再显着。相比之下，调整甘油三酸酯后，无论HAART状况如何，HIV感染仍与小HDL-p的第10、25、50、75和90％百分比显着降低有关。结论：我们的研究结果表明，在评估CVD风险时，对LDL-p的测试除了甘油三酸酯水平外，几乎没有其他信息。需要进一步调查以检查HDL-p在女性HIV和CVD之间的联系中的作用。

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