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首页> 外文期刊>Journal of cardiac surgery. >Del Nido cardioplegia for minimally invasive aortic valve replacement
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Del Nido cardioplegia for minimally invasive aortic valve replacement

机译：Del Nido Cardioplegia用于微创主动脉瓣更换

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Abstract Background We analyzed the impact and safety of del Nido Cardioplegia (DNC) in patients undergoing minimally invasive aortic valve replacement (MIAVR). Methods We analyzed all isolated MIAVR replacements from 5/2013‐6/2015 excluding re‐operative patients. The approach was a hemi‐median sternotomy in all patients. Patients were divided into two cohorts, those who received 4:1 crystalloid:blood DNC solution and those in whom standard 1:4 Buckberg‐based cardioplegia (WBC) was used. One‐to‐one propensity case matching of DNC to WBC was performed based on standard risk factors and differences between groups were analyzed using chi‐square and non‐parametric methods. Results MIAVR was performed in 181 patients; DNC was used in 59 and WBC in 122. Case matching resulted in 59 patients per cohort. DNC was associated with reduced re‐dosing (5/59 (8.5%) versus 39/59 (61.0%), P ??0.001) and less total cardioplegia volume (1290?±?347?mL vs 2284?±?828?mL, P ??0.001). Antegrade cardioplegia alone was used in 89.8% (53/59) of DNC patients versus 33.9% (20/59) of WBC patients ( P ??0.001). Median bypass and aortic cross‐clamp times were similar. Clinical outcomes were similar with respect to post‐operative hematocrit, transfusion requirements, need for inotropic/pressor support, duration of intensive care unit stay, re‐intubation, length of stay, new onset atrial fibrillation, and mortality. Conclusions Del Nido cardioplegia usage during MIAVR minimized re‐dosing and the need for retrograde delivery. Patient safety was not compromised with this technique in this group of low‐risk patients undergoing MIAVR.
机译：摘要背景我们分析了Del Nido心脏病（DNC）在经历微创主动脉瓣置换（MIAVR）患者中的影响和安全性。方法分析了来自5/2013-6 / 2015的所有孤立的MIAVR更换，不包括重新操作患者。该方法是所有患者的半中位数术骨术。患者分为两位队列，那些接受4：1晶体的人：使用血液DNC溶液和其中标准1：4基于Buckberg的心脏病（WBC）的那些。基于标准危险因素进行DNC至WBC的一对一倾向匹配，并使用Chi-Square和非参数方法分析组之间的差异。结果MIAVR于181名患者进行; DNC在59和WBC中使用122.案例匹配导致每组群体59名患者。 DNC与再计量减少（5/59（8.5％）而与39/59（61.0％），p≤≤0.001）和较少的总心脏停搏体积（1290？±347毫升2284？ 828？ml，p？0.001）。单独的疾病患者的89.8％（53/59）的促进心脏病与WBC患者的33.9％（20/59）使用（P = 0.001）。中位旁路和主动脉交叉夹时间相似。临床结果对于术后血细胞比容，输血要求，需要渗透性/压力载体，重症监护持续时间，重症监护持续时间，重新插管，住院长度，新发起心房颤动和死亡率。结论MIAVR在MIAVR最小化的再加药和逆行交付需求的结论。患者安全性并未受到该组织在麦克风的低风险患者中的这种技术损害。

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