...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>AIDS >Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men
【24h】

Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men

机译：HIV感染者中通过冠状动脉计算机断层造影血管造影术增加冠状动脉粥样硬化斑块易损性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: Among HIV-infected patients, high rates of myocardial infarction (Ml) and sudden cardiac death have been observed. Exploring potential underlying mechanisms, we used multidetector spiral coronary computed tomography angiography (coronary CTA) to compare atherosclerotic plaque morphology in HIV-infected patients and non-HIV-infected controls.Methods: Coronary atherosclerotic plaques visualized by CTA in HIV-infected (101) and non-HIV-infected (41) men without clinically apparent heart disease matched on cardiovascular risk factors were analyzed for three vulnerability features: low attenuation, positive remodeling, and spotty calcification.Results: Ninety-five percent of HIV-infected patients were receiving ART (median duration 7.9 years) and had well controlled disease (median CD4 cell count, 473 cells/mul; median HIV RNA <50 copies/ml). Age and traditional cardiovascular risk factors were similar in HIV-infected patients and controls. Among the HIV-infected (versus control) group, there was a higher prevalence of patients with at least one: low attenuation plaque (22.8 versus 7.3%, P = 0.02), positively remodeled plaque (49.5 versus 31.7%, P = 0.05) and high-risk 3-feature plaque (7.9 versus 0%, P = 0.02). Moreover, patients in the HIV-infected (versus control) group demonstrated a higher number of low attenuation plaques (P = 0.01) and positively remodeled plaques (P = 0.03) per patient.Conclusion: Our data demonstrate an increased prevalence of vulnerable plaque features among relatively young HIV-infected patients. Differences in coronary atherosclerotic plaque morphology - namely, increased vulnerable plaque among HIV-infected patients - are here for the first time reported and may contribute to increased rates of Ml and sudden cardiac death in this population.
机译：目的：在HIV感染的患者中，观察到较高的心肌梗塞（M1）和心源性猝死。为了探索潜在的潜在机制，我们使用了多层螺旋CT血管造影（冠状动脉CTA）来比较HIV感染患者和非HIV感染者的动脉粥样硬化斑块形态。方法：CTA观察HIV感染者的冠状动脉粥样硬化斑块（101）与非HIV感染（41）没有临床明显心脏病的心血管危险因素匹配的男性进行了三个易损性特征分析：低衰减，重塑阳性和斑点钙化。结果：95％的HIV感染患者正在接受治疗ART（病程中位数7.9年），且疾病得到良好控制（CD4细胞数中位数为473细胞/ mul; HIV RNA中位数<50拷贝/ ml）。艾滋病毒感染患者和对照组的年龄和传统心血管危险因素相似。在HIV感染（相对于对照组）组中，至少有以下患者的患病率更高：低衰减斑块（22.8对7.3％，P = 0.02），正重构斑块（49.5对31.7％，P = 0.05）和高风险3特征斑块（7.9对0％，P = 0.02）。此外，HIV感染（相对于对照组）组的患者表现出更多的低衰减斑块（P = 0.01）和正重构斑块（P = 0.03）。结论：我们的数据表明易损斑块特征的患病率增加在相对年轻的HIV感染患者中。首次报道了冠状动脉粥样硬化斑块形态的差异（即，HIV感染患者中易感斑块的增加），可能导致该人群的M1发生率增加和心脏猝死。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号