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首页> 外文期刊>Journal of cardiology >Comparison of the efficacies of disopyramide, cibenzoline and aprindine for the termination of paroxysmal and persistent atrial fibrillation in elderly and non-elderly patients
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Comparison of the efficacies of disopyramide, cibenzoline and aprindine for the termination of paroxysmal and persistent atrial fibrillation in elderly and non-elderly patients

机译：二羟基胺，西唑啉和酮肽在老年人和非老年患者终止术中术后性颤动终止的疗效的比较

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摘要

OBJECTIVES: The relationship between the efficacy of the anticholinergic action of disopyramide, cibenzoline and aprindine and age was examined in patients with paroxysmal and persistent atrial fibrillation. METHODS: This prospective, randomized study included 278 patients (200 men, 78 women, mean age 61 +/- 11 years) divided into two groups; the non-elderly group (age below 60 years) and the elderly group (age over 60 years). Successful termination was defined as conversion of sinus rhythm within 30 min of intravenous administration of 50 mg disopyramide (n = 91), 70 mg cibenzoline (n = 93) or 100 mg aprindine (n = 94) in this prospective and randomized study. RESULTS: No statistically significant difference was found in patient characteristics between the three agents. 1) The rate of conversion to sinus rhythm after disopyramide administration in the non-elderly group(37.8%) was significantly higher than that in the elderly group (17.4%, p = 0.0361). 2) The rate of conversion to sinus rhythm after cibenzoline administration in the non-elderly group (62.2%) tended to be greater than that in the elderly group (43.8%, p = 0.0972). 3) The rate of conversion to sinus rhythm after aprindine administration in the non-elderly group (25.6%) was not significantly higher than that in the elderly group (18.2%, p = 0.4474). CONCLUSIONS: The anticholinergic action of antiarrhythmic agents has an effect on successful termination in non-elderly patients with paroxysmal and persistent atrial fibrillation.
机译：目的：在阵发性和持续的心房颤动的患者中检查二甲酰胺，西唑啉和肽和年龄和年龄的抗胆碱能作用的疗效之间的关系。方法：这项前瞻性，随机研究包括278名患者（200名男子，78名女性，平均61 +/- 11岁）分为两组;非老年群（60岁以下）和老年人（60多年）。在该前瞻性和随机研究中，成功​​终止在静脉内施用50mg二甲酰胺（n = 91），70mg香唑啉（n = 93）或100mg Applindine（n = 94）中，在静脉内施用的30分钟内转化为鼻窦节律。结果：在三种试剂之间的患者特征中没有发现统计学上的差异。 1）在非老年基团的二甲酰胺施用后对窦性能的转化率（37.8％）明显高于老年基团（17.4％，P = 0.0361）。 2）在非老年基团中的西唑啉酮局（62.2％）后窦性能转化率（62.2％）往大于老年基团（43.8％，P = 0.0972）。 3）在非老年基团（25.6％）中，在非老年群体施用后对窦性节律的转化率并未显着高于老年组（18.2％，P = 0.4474）。结论：抗心律失常药物的抗胆碱能作用对非老年患者的阵发性和持续性心房颤动的患者成功终止作用。

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  • 来源
    《Journal of cardiology》 |2003年第4期|共8页
  • 作者

    Komatsu T; Nakamura S; Suzuki O; Yomogida K; Horiuchi D; Abe N; Kameda K; Owada S; Tomita H; Oikawa K; Okumura K;

  • 作者单位

    Division of Cardiology Department of Internal Medicine Iwate Prefectural Iwai Hospital Maeda 13 Yamanome Ichinoseki Iwate 021-8533.;

    The Jackson Laboratory 600 Main Street Bar Harbor ME 04609 USA;

    The Jackson Laboratory 600 Main Street Bar Harbor ME 04609 USA;

    The Jackson Laboratory 600 Main Street Bar Harbor ME 04609 USA;

    The Jackson Laboratory 600 Main Street Bar Harbor ME 04609 USA;

    The Jackson Laboratory 600 Main Street Bar Harbor ME 04609 USA;

    The Jackson Laboratory 600 Main Street Bar Harbor ME 04609 USA;

    The Jackson Laboratory 600 Main Street Bar Harbor ME 04609 USA;

    The Jackson Laboratory 600 Main Street Bar Harbor ME 04609 USA;

    The Jackson Laboratory 600 Main Street Bar Harbor ME 04609 USA;

    The Jackson Laboratory 600 Main Street Bar Harbor ME 04609 USA;

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  • 原文格式 PDF
  • 正文语种 jpn
  • 中图分类 心脏、血管（循环系）疾病;
  • 关键词

    Elderly; cifenline; Disopyramide; Atrial Fibrillation; Age; NOS; 丙吡胺; 心房颤动;

    机译：Elderly;cifenline;Disopyramide;Atrial Fibrillation;Age;NOS;丙吡胺;心房颤动;

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